随着传代次数增加，体细胞杂交系的抗肿瘤免疫原性丧失。
Loss of anti-tumour immunogenicity of a somatic cell hybrid line with increasing subculture.
作者信息
Favre R, Carcassonne Y, Meyer G
出版信息
Br J Cancer. 1975 Jul;32(1):139-41. doi: 10.1038/bjc.1975.140.
Abstract
Good immunoprotection was afforded by A9/SEWA somatic hybrid cells in the C3H mouse/C3H Py tumour system, confirming results previously obtained in the A.SW mouse/SEWA tumour system. However, in this study the immunogenicity decreased with increasing serial subculture of the hybrid line and concomitant chromosome loss.
摘要
在C3H小鼠/C3H Py肿瘤系统中，A9/SEWA体细胞杂交细胞提供了良好的免疫保护作用，这证实了先前在A.SW小鼠/SEWA肿瘤系统中获得的结果。然而，在本研究中，随着杂交系连续传代培养次数的增加以及伴随的染色体丢失，免疫原性降低。
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