补体介导的针对人类7号染色体编码抗原的抗血清细胞毒性反应：人-鼠体细胞杂种中重排的人类7号染色体的免疫选择
Complement-mediated antiserum cytotoxic reactions to human chromosome 7 coded antigen(s): immunoselection of rearranged human chromosome 7 in human-mouse somatic cell hybrids.
作者信息
Knowles B B, Solter D, Trinchieri G, Maloney K M, Ford S R, Aden D P
出版信息
J Exp Med. 1977 Feb 1;145(2):314-26. doi: 10.1084/jem.145.2.314.
Abstract
Immunoselection via complement-dependent lysis of human-mouse somatic cell hybrids containing chromosome 7, with antisera reactive to cell surface antigen(s) coded for by chromosome 7, has resulted in growth of somatic cell hybrids containing rearranged human chromosome 7s. Investigation of these hybrids has localized the gene(s) coding for the relevant cell surface antigen(s) to the short arm of human chromosome 7. The simian virus 40 integration site and the gene coding for human beta-glucuronidase appear to be localized to the long arm of chromosome 7 in this hybrid clone.
摘要
通过对含有7号染色体的人-鼠体细胞杂种进行补体依赖裂解的免疫选择，利用与7号染色体编码的细胞表面抗原发生反应的抗血清，已获得了含有重排人7号染色体的体细胞杂种的生长。对这些杂种的研究已将编码相关细胞表面抗原的基因定位到人类7号染色体的短臂上。在这个杂种克隆中，猿猴病毒40整合位点和编码人β-葡萄糖醛酸酶的基因似乎定位在7号染色体的长臂上。
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