金催化的高炔丙醇的串联环异构化-氢烷氧基化反应
Gold-catalyzed tandem cycloisomerization-hydroalkoxylation of homopropargylic alcohols.
作者信息
Belting Volker, Krause Norbert
机构信息
Organic Chemistry II, Dortmund University, D-44221 Dortmund, Germany.
出版信息
Org Lett. 2006 Sep 28;8(20):4489-92. doi: 10.1021/ol061751u.
PMID:16986932
Abstract
The tandem cycloisomerization-hydroalkoxylation of various homopropargylic alcohols in the presence of an alcohol and a dual catalyst system, consisting of a gold precatalyst and a Brønsted acid, provides an efficient route to tetrahydrofuranyl ethers under mild reaction conditions. The reaction can be carried out in various solvents, including alcohol, with both terminal and internal alkynes as the substrate.
摘要
在醇以及由金预催化剂和布朗斯特酸组成的双催化剂体系存在下，各种高炔丙醇的串联环异构化-氢烷氧基化反应，在温和的反应条件下为四氢呋喃基醚提供了一条有效合成路线。该反应可以在包括醇在内的各种溶剂中进行，以末端炔烃和内炔烃作为底物均可。
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