金催化炔键连接的二氢嘧啶酮环化反应。
Gold catalyzed cyclization of alkyne-tethered dihydropyrimidones.
机构信息
Department of Chemistry and Center for Chemical Methodology and Library Development, Life Sciences and Engineering Building, Boston University, 24 Cummington Street, Boston, Massachusetts 02215, USA.
出版信息
Org Lett. 2011 Aug 19;13(16):4228-31. doi: 10.1021/ol2015658. Epub 2011 Jul 13.
Abstract
Dihydropyrimidones are an important class of biologically active heterocycles accessible from the multicomponent Biginelli condensation. Further manipulation of the dihydropyrimidone skeleton gives access to unique heterocycles. Presented herein is a Au-catalyzed cyclization of alkyne-tethered dihydropyrimidones to yield pyridopyrimidones.
摘要
二氢嘧啶酮是一类重要的具有生物活性的杂环化合物，可以通过多组分的Biginelli 缩合反应得到。进一步对二氢嘧啶酮骨架进行操作，可以得到独特的杂环化合物。本文报道了炔烃键合的二氢嘧啶酮在金催化下环化生成吡啶并嘧啶酮。
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