Wender Paul A, Horan Joshua C
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
Org Lett. 2006 Sep 28;8(20):4581-4. doi: 10.1021/ol0618149.
The design, asymmetric synthesis, and biological evaluation of a new class of bryostatin analogues based on a pseudosymmetric spacer domain are described. An aryl bromide diversification site is incorporated allowing access to systematically varied analogues. The new analogues all exhibit potent, nanomolar affinity to PKC.
描述了基于假对称间隔域的一类新型苔藓抑素类似物的设计、不对称合成及生物学评价。引入了芳基溴多样化位点，从而能够获得系统变化的类似物。所有新类似物均对蛋白激酶C表现出强效的纳摩尔亲和力。
