通过分子内Pauson-Khand反应合成生物素的酮类似物。
Synthesis of a ketone analogue of biotin via the intramolecular Pauson-Khand reaction.
作者信息
McNeill Eric, Chen Irwin, Ting Alice Y
机构信息
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 18-496, Cambridge, Massachusetts 02139, USA.
出版信息
Org Lett. 2006 Sep 28;8(20):4593-5. doi: 10.1021/ol061862t.
Abstract
We report an improved synthesis of 5-(5-oxohexahydrocyclopenta[c]thiophen-1-yl)pentanoic acid (ketone biotin, 1) based on the intramolecular Pauson-Khand cyclization. The synthesis proceeds in eight steps and in 2.7% overall yield from cyclohexene.
摘要
我们报道了一种基于分子内Pauson-Khand环化反应改进的5-(5-氧代六氢环戊[c]噻吩-1-基)戊酸（酮生物素，1）的合成方法。该合成从环己烯开始，经过八步反应，总产率为2.7%。
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