（-）-亚因卡纳定A和B的首次不对称全合成，它们是蛇根草中亚因卡纳中的骨架重排五环单萜吲哚生物碱。
First asymmetric total syntheses of (-)-subincanadines a and B, skeletally rearranged pentacyclic monoterpenoid indole alkaloids in aspidospermasubincanum.
作者信息
Suzuki Kenta, Takayama Hiromitsu
机构信息
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
出版信息
Org Lett. 2006 Sep 28;8(20):4605-8. doi: 10.1021/ol061908i.
PMID:16986961
Abstract
We achieved the first asymmetric total syntheses of novel Aspidosperma indole alkaloids, (-)-subincanadines A and B, which involve an intramolecular diastereoselective Pictet-Spengler cyclization and an intramolecular Nozaki-Hiyama-Kishi reaction as key steps in the total syntheses.
摘要
我们首次完成了新型阿西多斯佩尔马吲哚生物碱（-）-亚因卡纳定A和B的不对称全合成，其中分子内非对映选择性皮克特-施彭格勒环化反应和分子内野崎-日山-岸反应是全合成中的关键步骤。
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