通过基于分子内Heck环化反应的新型通用合成途径对阿朴菲生物碱进行形式上的全合成。
Formal total syntheses of aspidosperma alkaloids via a novel and general synthetic pathway based on an intramolecular Heck cyclization.
作者信息
Pereira Jennifer, Barlier Mireille, Guillou Catherine
机构信息
Institut de Chimie des Substances Naturelles, Bt 27, CNRS Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
出版信息
Org Lett. 2007 Aug 2;9(16):3101-3. doi: 10.1021/ol0712576. Epub 2007 Jul 13.
PMID:17629291
Abstract
Cyclizations of bicyclic amides via an intramolecular Heck reaction followed by an oxidation reaction generate tricyclic spirocyclohexadienones. From these compounds, tetracyclic ketones can be synthesized to provide useful intermediates for the synthesis of indole alkaloids.
摘要
通过分子内Heck反应随后进行氧化反应，双环酰胺发生环化反应生成三环螺环己二烯酮。从这些化合物中，可以合成四环酮，为吲哚生物碱的合成提供有用的中间体。
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