Lagodzinski Z, Górski A, Wasik M
Department of Immunology, Transplantation Institute, Warsaw Medical School, Poland.
Immunology. 1990 Sep;71(1):148-50.
The ability of FK506 and cyclosporine to prolong mouse skin allograft survival when given alone and in combination was studied during primary and secondary responses. The drugs were efficient immunosuppressants of both types of anti-graft responses but--as reported earlier--much lower FK506 doses were required to produce those effects. Both agents synergized when administered together during primary responses but not secondary responses. This suggests that the combination treatment may be less successful in a presensitized host, a finding with potential clinical application.
在初次和二次反应期间，研究了单独使用和联合使用FK506和环孢素延长小鼠皮肤同种异体移植存活时间的能力。这两种药物对两种类型的抗移植反应均为有效的免疫抑制剂，但正如之前报道的那样，产生这些效应所需的FK506剂量要低得多。在初次反应期间一起给药时，两种药物具有协同作用，但在二次反应期间则不然。这表明联合治疗在预先致敏的宿主中可能不太成功，这一发现具有潜在的临床应用价值。
