Altiner D D, Ilknur T, Fetil E, Günes A T, Ozkan S
Department of Dermatology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey.
J Eur Acad Dermatol Venereol. 2006 Oct;20(9):1076-80. doi: 10.1111/j.1468-3083.2006.01703.x.
Different protocols have been used for narrowband ultraviolet B (UVB) therapy, commonly used in the treatment of psoriasis; however, more effective and reliable protocols are still required.
The aim of this study was to compare the weekly and daily dose increment protocols of narrowband UVB phototherapy in psoriasis patients.
Thirty patients with plaque psoriasis underwent narrowband UVB treatment three times a week and 15 patients selected consecutively among these patients underwent a weekly (once in three treatments) dose increment whereas the remaining 15 patients underwent a daily dose increment. Patients were monitored for 10 weeks and evaluated by the Psoriasis Area Severity Index (PASI).
When the two groups were evaluated according to median PASI scores prior to the treatment and during 10 weeks of treatment, there was no statistically significant difference between the groups (P > 0.05). During the treatment lasting for 10 weeks, four patients in the group with a weekly dose increment and three patients in the group with a daily dose increment recovered and no statistically significant difference was detected between the groups (P > 0.05). The groups were also evaluated according to the median cumulative dose. The median cumulative dose was higher in the group with a daily dose increment and the difference between the groups was statistically significant (P = 0.002).
The application of daily dose increments was no better than that of weekly dose increments in narrowband UVB treatment for psoriasis. Therefore, although our results may need to be supported by large-series studies, we conclude that application of weekly dose increments with a lower cumulative dose having the same efficacy is preferred in narrowband UVB treatment of psoriasis.
窄谱中波紫外线（UVB）疗法有不同的方案，常用于治疗银屑病；然而，仍需要更有效和可靠的方案。
本研究旨在比较银屑病患者窄谱UVB光疗的每周剂量递增方案和每日剂量递增方案。
30例斑块状银屑病患者每周接受3次窄谱UVB治疗，在这些患者中连续选取15例患者采用每周（三次治疗中的一次）剂量递增，其余15例患者采用每日剂量递增。对患者进行10周的监测，并通过银屑病面积和严重程度指数（PASI）进行评估。
根据治疗前和治疗10周期间的PASI中位数评分对两组进行评估时，两组之间无统计学显著差异（P>0.05）。在持续10周的治疗期间，每周剂量递增组有4例患者、每日剂量递增组有3例患者痊愈，两组之间未检测到统计学显著差异（P>0.05）。还根据累积剂量中位数对两组进行评估。每日剂量递增组的累积剂量中位数更高，两组之间的差异具有统计学显著性（P = 0.002）。
在银屑病的窄谱UVB治疗中，每日剂量递增的应用并不优于每周剂量递增。因此，尽管我们的结果可能需要大样本研究的支持，但我们得出结论，在银屑病的窄谱UVB治疗中，优选累积剂量较低且疗效相同的每周剂量递增方案。
