Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Photodermatol Photoimmunol Photomed. 2010 Feb;26(1):10-5. doi: 10.1111/j.1600-0781.2009.00473.x.
Narrowband ultraviolet B (NB-UVB) phototherapy is an effective treatment for psoriasis.
To compare the effects of three and five times weekly NB-UVB phototherapy in the treatment of chronic plaque psoriasis.
Sixty-five patients with chronic plaque psoriasis were allocated to receive three or five times weekly NB-UVB, starting at low dose.
Among the patients who completed the study, clearance was achieved in 18 out of 23 patients (78%) in the three times weekly group and in 15 out of 22 patients (68%) in the five times weekly group. The difference was not statistically significant (P=0.44). No statistically significant differences were found between the two groups in the number of treatments (P=0.95), cumulative UVB dose (P=0.51), and rate of side-effects. Length of the treatment period was significantly shorter in the five times weekly group (P<0.001). At the end of treatment, the mean psoriasis area and severity index score was lower in the three times weekly group (P=0.02).
We recommend three times weekly NB-UVB for chronic plaque psoriasis; however, the more rapid clearance of psoriasis with five times weekly phototherapy may justify using this method in some patients.
窄谱中波紫外线（NB-UVB）光疗是治疗银屑病的有效方法。
比较每周三次和每周五次 NB-UVB 光疗治疗慢性斑块状银屑病的效果。
将 65 例慢性斑块状银屑病患者分配至每周三次或每周五次 NB-UVB 治疗组，起始剂量较低。
在完成研究的患者中，每周三次组 23 例患者中有 18 例（78%）达到清除，每周五次组 22 例患者中有 15 例（68%）达到清除。差异无统计学意义（P=0.44）。两组在治疗次数（P=0.95）、累积 UVB 剂量（P=0.51）和不良反应发生率方面无统计学差异。每周五次组的治疗周期明显缩短（P<0.001）。治疗结束时，每周三次组的银屑病面积和严重程度指数评分均值较低（P=0.02）。
我们建议每周三次 NB-UVB 治疗慢性斑块状银屑病；然而，每周五次光疗可更快清除银屑病，这可能使其在某些患者中具有合理性。
