用一种新型活化衍生物将柔红霉素与单克隆抗甲胎蛋白偶联。
Coupling daunorubicin to monoclonal antialphafoetoprotein with a new activated derivative.
作者信息
Thibeault D, Pagé M
机构信息
Department of Biochemistry, Faculty of Medicine, Université Laval, Sainte-Foy, Québec, Canada.
出版信息
Int J Immunopharmacol. 1990;12(5):503-7. doi: 10.1016/0192-0561(90)90113-2.
PMID:1698734
Abstract
We report the synthesis of daunorubicin antialphafoetoprotein conjugates, using a new coupling method. At equimolar concentrations on AFP producing cells in vitro, these conjugates were found three times as cytotoxic as the free drug.
摘要
我们报告了使用一种新的偶联方法合成柔红霉素抗甲胎蛋白缀合物。在体外对产生甲胎蛋白的细胞采用等摩尔浓度时，发现这些缀合物的细胞毒性是游离药物的三倍。
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