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通过连续磁共振成像、活检、体外培养、免疫荧光分析和分子分析结果的相互关联诊断出的酷似中风的致命性肉芽肿性棘阿米巴脑炎。

Fatal granulomatous Acanthamoeba encephalitis mimicking a stroke, diagnosed by correlation of results of sequential magnetic resonance imaging, biopsy, in vitro culture, immunofluorescence analysis, and molecular analysis.

作者信息

McKellar Mehri S, Mehta Lahar R, Greenlee John E, Hale Devon C, Booton Gregory C, Kelly Daryl J, Fuerst Paul A, Sriram Rama, Visvesvara Govinda S

机构信息

Division of Infectious Diseases, Department of Internal Medicine, University of Utah, Salt Lake City 84132-2405, USA.

出版信息

J Clin Microbiol. 2006 Nov;44(11):4265-9. doi: 10.1128/JCM.00649-06. Epub 2006 Sep 20.

DOI:10.1128/JCM.00649-06
PMID:16988022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1698355/
Abstract

Amebic infections involving the central nervous system are rare and difficult to diagnose. Magnetic resonance imaging (MRI) at timed intervals may be helpful, where scans reveal enhancing lesions and increased signal. We report a unique case of granulomatous amebic encephalitis that was proven pathologically with progressive radiological findings on MRI.

摘要

累及中枢神经系统的阿米巴感染罕见且难以诊断。定期进行磁共振成像（MRI）检查可能会有帮助，扫描显示有强化病变和信号增强。我们报告了一例肉芽肿性阿米巴脑炎的独特病例，该病例经病理证实，MRI上有进行性的影像学表现。

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Fatal granulomatous Acanthamoeba encephalitis mimicking a stroke, diagnosed by correlation of results of sequential magnetic resonance imaging, biopsy, in vitro culture, immunofluorescence analysis, and molecular analysis.通过连续磁共振成像、活检、体外培养、免疫荧光分析和分子分析结果的相互关联诊断出的酷似中风的致命性肉芽肿性棘阿米巴脑炎。
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本文引用的文献

1
Inability to make a premortem diagnosis of Acanthamoeba species infection in a patient with fatal granulomatous amebic encephalitis.无法对患有致命性肉芽肿性阿米巴脑炎的患者进行棘阿米巴属感染的生前诊断。
J Clin Microbiol. 2005 Jun;43(6):3003-6. doi: 10.1128/JCM.43.6.3003-3006.2005.
2
Identification and distribution of Acanthamoeba species genotypes associated with nonkeratitis infections.与非角膜炎感染相关的棘阿米巴物种基因型的鉴定与分布。
J Clin Microbiol. 2005 Apr;43(4):1689-93. doi: 10.1128/JCM.43.4.1689-1693.2005.
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Free-living amoebae as opportunistic and non-opportunistic pathogens of humans and animals.自由生活阿米巴作为人和动物的机会性和非机会性病原体。
Int J Parasitol. 2004 Aug;34(9):1001-27. doi: 10.1016/j.ijpara.2004.06.004.
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Successful treatment of Balamuthia amoebic encephalitis: presentation of 2 cases.巴拉姆希阿米巴脑炎的成功治疗：2例病例报告
Clin Infect Dis. 2003 Nov 15;37(10):1304-12. doi: 10.1086/379020. Epub 2003 Oct 17.
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Amebic encephalitis caused by Balamuthia mandrillaris: report of four cases.由曼氏巴贝斯虫引起的阿米巴性脑炎：4例报告
Pediatr Infect Dis J. 2003 May;22(5):447-53. doi: 10.1097/01.inf.0000066540.18671.f8.
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Acanthamoeba spp. as agents of disease in humans.棘阿米巴属作为人类疾病的病原体。
Clin Microbiol Rev. 2003 Apr;16(2):273-307. doi: 10.1128/CMR.16.2.273-307.2003.
7
An autopsy case of amebic meningoencephalitis. The first Japanese case caused by Balamuthia mandrillaris.一例阿米巴脑膜脑炎尸检病例。日本首例由曼氏巴通体引起的病例。
Neuropathology. 2002 Sep;22(3):213-7. doi: 10.1046/j.1440-1789.2002.00444.x.
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Disseminated acanthamebiasis in a renal transplant recipient with osteomyelitis and cutaneous lesions: case report and literature review.肾移植受者并发播散性棘阿米巴病伴骨髓炎和皮肤病变：病例报告及文献复习
Clin Infect Dis. 2002 Sep 1;35(5):e43-9. doi: 10.1086/341973. Epub 2002 Aug 2.
9
Use of subgenic 18S ribosomal DNA PCR and sequencing for genus and genotype identification of acanthamoebae from humans with keratitis and from sewage sludge.利用亚基因18S核糖体DNA聚合酶链反应和测序技术对来自角膜炎患者及污水污泥中的棘阿米巴进行属和基因型鉴定。
J Clin Microbiol. 2001 May;39(5):1903-11. doi: 10.1128/JCM.39.5.1903-1911.2001.
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