Kaczmarek Leonard K
Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA.
Nat Rev Neurosci. 2006 Oct;7(10):761-71. doi: 10.1038/nrn1988.
Various studies, mostly in the past 5 years, have demonstrated that, in addition to their well-described function in regulating electrical excitability, voltage-dependent ion channels participate in intracellular signalling pathways. Channels can directly activate enzymes linked to cellular signalling pathways, serve as cell adhesion molecules or components of the cytoskeleton, and their activity can alter the expression of specific genes. Here, I review these findings and discuss the extent to which the molecular mechanisms of such signalling are understood.
各类研究（大多是过去5年开展的）表明，除了在调节电兴奋性方面广为人知的功能外，电压依赖性离子通道还参与细胞内信号传导途径。这些通道可以直接激活与细胞信号传导途径相关的酶，充当细胞粘附分子或细胞骨架的组成部分，并且它们的活性能够改变特定基因的表达。在此，我将对这些研究结果进行综述，并探讨我们对这种信号传导分子机制的了解程度。
