Pan Yifei, Pan Cong, Mao Lanqun, Yu Ping
Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
College of Chemistry, Beijing Normal University, Beijing 100875, China.
Fundam Res. 2024 Apr 12;5(1):55-62. doi: 10.1016/j.fmre.2024.04.010. eCollection 2025 Jan.
Chemicals play a crucial role in neurophysiological and neuropathological processes. By regulating the concentration of specific chemicals, receptors on the neuron cell membrane can be modulated to activate or inhibit, thereby influencing specific ion channels and facilitating neuromodulation. This review introduces several chemical modulation techniques, such as microinjection, electrode/nanoparticle-based chemical delivery methods, electrochemical synthesis and chemogenetics. While these techniques show promise in expanding the application of chemical neuromodulation, they currently exhibit different degrees of shortcomings and room for improvement. This review summarizes the opportunities and challenges for chemical neuromodulation methods and provide an outlook for their prospects in the future.
化学物质在神经生理和神经病理过程中起着至关重要的作用。通过调节特定化学物质的浓度，可以调节神经元细胞膜上的受体以激活或抑制，从而影响特定的离子通道并促进神经调节。本文综述了几种化学调制技术，如显微注射、基于电极/纳米颗粒的化学递送方法、电化学合成和化学遗传学。虽然这些技术在扩大化学神经调节的应用方面显示出前景，但目前它们都存在不同程度的缺点和改进空间。本文总结了化学神经调节方法面临的机遇和挑战，并对其未来前景进行了展望。
