Eparvier Véronique, Nguyen Van Hung, Thoison Odile, Martin Marie-Thérèse, Sévenet Thierry, Guéritte Françoise
Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
J Nat Prod. 2006 Sep;69(9):1289-94. doi: 10.1021/np060168j.
The known plagionicin A (1) and eight new monotetrahydrofuran acetogenins, plagionicins B-D (2-4) and plagioneurins A-E (5-9), were isolated from the leaves of Disepalum plagioneurum by bioassay-guided purification. The structures of the new compounds were elucidated by spectroscopic methods. The new monotetrahydrofuran (mono-THF) acetogenins exhibited significant in vitro cytotoxicity against the KB cancer cell line, with IC(50) values in the nanomolar range.
通过生物活性导向分离法，从斜瓣花属植物Disepalum plagioneurum的叶子中分离得到了已知的斜瓣花素A（1）以及8种新的单四氢呋喃类产乙酸菌素，即斜瓣花素B-D（2-4）和斜瓣花神经素A-E（5-9）。通过光谱方法阐明了这些新化合物的结构。这些新的单四氢呋喃（单-THF）类产乙酸菌素对KB癌细胞系表现出显著的体外细胞毒性，其半数抑制浓度（IC50）值在纳摩尔范围内。
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