蒙他辛和顺式蒙他辛，两种从山地番荔枝中分离得到的具有细胞毒性的新型单四氢呋喃类番荔枝内酯。

Montacin and cis-montacin, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona montana.

作者信息

Liaw Chih-Chuang, Chang Fang-Rong, Wu Yang-Chang, Wang Hui-Kang, Nakanishi Yuka, Bastow Kenneth F, Lee Kuo-Hsiung

机构信息

Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.

出版信息

J Nat Prod. 2004 Nov;67(11):1804-8. doi: 10.1021/np030216p.

DOI:10.1021/np030216p

PMID:15568766

Abstract

Two new monotetrahydrofuran Annonaceous acetogenins, montacin (1), and cis-montacin (2), along with four known acetogenins, annonacin, cis-annonacin, annomontacin, and cis-annomontacin, were isolated from the seeds of Annona montana. The structures of the new isolates were elucidated by spectral and chemical methods. The new acetogenins exhibited moderate in vitro cytotoxic activity against the 1A9 human ovarian cancer cell line. Interestingly, when Ca(2+) was present, compounds 1 and 2 became 3- to 10-fold more active against 1A9 cells and the PTX10 subline.

摘要

从蒙塔纳番荔枝的种子中分离出两种新的单四氢呋喃番荔枝乙素，蒙他辛（1）和顺式蒙他辛（2），以及四种已知的番荔枝乙素，番荔枝acin、顺式番荔枝acin、番荔枝蒙他辛和顺式番荔枝蒙他辛。通过光谱和化学方法阐明了新分离物的结构。新的番荔枝乙素对1A9人卵巢癌细胞系表现出中等程度的体外细胞毒性活性。有趣的是，当存在Ca(2+)时，化合物1和2对1A9细胞和PTX10亚系的活性提高了3至10倍。