罗利内酯A和B：来自多鳞番荔枝的两种新型生物活性番荔枝内酯
Rollinecins A and B: two new bioactive annonaceous acetogenins from Rollinia mucosa.
作者信息
Shi G, Ye Q, He K, McLaughlin J L, MacDougal J M
机构信息
Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
出版信息
J Nat Prod. 1996 May;59(5):548-51. doi: 10.1021/np960128n.
Two new mono-THF ring acetogenins, rollinecins A (1) and B (2), were isolated from the partitioned ethanolic extracts of the leaves of Rollinia mucosa (Annonaceae) by activity-directed fractionation. 1 and 2 are epimeric at the C-14 carbinol stereocenter. Their absolute stereochemical structures were solved by preparing their respective per-Mosher ester derivatives. 1 and 2 showed equivalent and selective in vitro activities against several human solid tumor cell lines.
通过活性导向分级分离，从番荔枝科植物圆滑番荔枝叶的乙醇提取物的分配物中分离出两种新的单四氢呋喃环番荔枝内酯，罗林菌素A（1）和B（2）。1和2在C-14甲醇立体中心处为差向异构体。通过制备它们各自的全莫舍尔酯衍生物确定了它们的绝对立体化学结构。1和2对几种人类实体瘤细胞系显示出同等且具有选择性的体外活性。
Zotero 插件