Ma Yunsheng, Pagoto Sherry L, Olendzki Barbara C, Hafner Andrea R, Perugini Richard A, Mason Robin, Kelly John J
Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Obes Surg. 2006 Sep;16(9):1227-31. doi: 10.1381/096089206778392284.
Weight loss after bariatric surgery varies and depends on many factors, such as time elapsed since surgery, baseline weight, and co-morbidities.
We analyzed weight data from 494 patients who underwent laparoscopic Roux-en-Y gastric bypass (RYGBP) by one surgeon at an academic institution between June 1999 and December 2004. Linear regression was used to identify factors in predicting % excess weight loss (%EWL) at 1 year.
Mean patient age at time of surgery was 44 +/- 9.6 (SD), and the majority were female (83.8%). The baseline prevalence of co-morbidities included 24% for diabetes, 42% for hypertension, and 15% for hypercholesterolemia. Baseline BMI was 51.5 +/- 8.5 kg/m(2). Mean length of hospital stay was 3.8 +/- 4.6 days. Mortality rate was 0.6%. Follow-up weight data were available for 90% of patients at 6 months after RYGBP, 90% at 1 year, and 51% at 2 years. Mean %EWL at 1 year was 65 +/- 15.2%. The success rate (> or = 50 %EWL) at 1 year was 85%. Younger age and lower baseline weight predicted greater weight loss. Males lost more weight than females. Diabetes was associated with a lower %EWL. Depression did not significantly predict %EWL.
The study demonstrated a 65 %EWL and 85% success rate at 1 year in our bariatric surgery program. Our finding that most pre-surgery co-morbidities and depression did not predict weight loss may have implications for pre-surgery screening.
减肥手术后的体重减轻情况各不相同，且取决于许多因素，如手术后经过的时间、基线体重和合并症。
我们分析了1999年6月至2004年12月期间在一所学术机构由一名外科医生实施腹腔镜Roux-en-Y胃旁路术（RYGBP）的494例患者的体重数据。采用线性回归来确定预测1年时超重体重减轻百分比（%EWL）的因素。
手术时患者的平均年龄为44±9.6（标准差）岁，大多数为女性（83.8%）。合并症的基线患病率包括糖尿病24%、高血压42%和高胆固醇血症15%。基线体重指数为51.5±8.5kg/m²。平均住院时间为3.8±4.6天。死亡率为0.6%。RYGBP术后6个月时90%的患者、1年时90%的患者以及2年时51%的患者有随访体重数据。1年时的平均%EWL为65±15.2%。1年时的成功率（≥50%EWL）为85%。年龄较小和基线体重较低预测体重减轻更多。男性比女性减重更多。糖尿病与较低的%EWL相关。抑郁症并未显著预测%EWL。
该研究表明我们的减肥手术项目在1年时的超重体重减轻百分比为65%，成功率为85%。我们的研究发现大多数术前合并症和抑郁症并未预测体重减轻，这可能对术前筛查有影响。
