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73例接受腹腔镜可调节胃束带术治疗的美国肥胖儿科患者的最新情况:合并症缓解及依从性数据

An update on 73 US obese pediatric patients treated with laparoscopic adjustable gastric banding: comorbidity resolution and compliance data.

作者信息

Nadler Evan P, Youn Heekoung A, Ren Christine J, Fielding George A

机构信息

Division of Pediatric Surgery, New York University School of Medicine, New York, NY 10016, USA.

出版信息

J Pediatr Surg. 2008 Jan;43(1):141-6. doi: 10.1016/j.jpedsurg.2007.09.035.

DOI:10.1016/j.jpedsurg.2007.09.035
PMID:18206472
Abstract

BACKGROUND

Adolescent obesity continues to present one of the most difficult and important challenges for both the pediatric and adult medical communities. Evidence is mounting that bariatric surgery is the only reliable method for substantial and sustainable weight loss; however, the debate continues with regard to the optimal surgical procedure for both adolescents and adults. Although most US adult bariatric surgeons prefer the gastric bypass, our institution has demonstrated equivalent weight loss with significantly less morbidity using laparoscopic adjustable gastric banding (LAGB) in both adults and adolescents. This analysis is an update of our results in our first 73 patients, including resolution of comorbid conditions and compliance data.

METHODS

All adolescents aged 13 to 17 years who have undergone LAGB at our institution have been entered into our prospectively collected database since September 2001 and were reviewed. Data collected preoperatively included age, sex, race, body mass index (BMI), and presence of comorbid conditions. Postoperatively recorded data included length of stay, operative morbidity, need for reoperation, percentage of excess weight loss (%EWL), and BMI at 3-month intervals; status of any comorbid conditions, and number of postoperative visits and band adjustments.

RESULTS

Seventy-three adolescents aged 13 to 17 years (mean, 15.8 +/- 1.2 years) have undergone LAGB at our institution since September, 2001. Of these, 54 were female and 19 were male. The mean preoperative weight was 298 lb, with a BMI of 48 kg/m(2). The %EWL at 6 months, 1 year, and 2 years postoperatively was 35% +/- 16%, 57% +/- 23%, and 61% +/- 27%, respectively. One patient experienced a gastric perforation after a reoperation for band replacement because of a slip. One additional patient requested band removal because of restriction intolerance after a slip. A total of 6 patients developed band slippage, and 3 patients developed symptomatic hiatal hernias. Nutritional complications included asymptomatic iron deficiency in 13 patients, asymptomatic vitamin D deficiency in 4 patients, and mild subjective hair loss in 14 patients. In 21 patients who entered our Food and Drug Administration-approved study and had reached 1-year follow-up, there were 51 identified comorbid conditions. Of these, 35 (68.5%) were completely resolved, 9 (17.5%) were improved, 5 (10%) were unchanged, and 2 (4%) were aggravated after 1 year. Of 50 initial patients who underwent surgery more than 1 year ago, 2 patients lived a large distance from our institution, where band maintenance is being performed locally, and thus, the patients were excluded from the analysis. Two patients were lost to follow-up in the first year, and 3 patients were lost to follow-up in the second year, for an overall compliance rate of at least 89.5%. The mean number of office visits was 10 +/- 3 in the first year, and the mean number of adjustments was 6 +/- 2.

CONCLUSIONS

Laparoscopic adjustable gastric banding continues to represent an attractive treatment strategy for morbidly obese pediatric patients with a %EWL of more than 55% at both 1- and 2-year follow-up, with minimal morbidity compared with the gastric bypass. Furthermore, the weight loss associated with LAGB provides excellent resolution or improvement of comorbid conditions. Although there is a necessary commitment by the patient that involves frequent office visits and band adjustments, adolescents are entirely capable of this commitment, and noncompliance should not be a reason to dissuade adolescents from having LAGB. It remains, in our opinion, the optimal surgical option for pediatric patients with morbid obesity.

摘要

背景

青少年肥胖问题仍然是儿科和成人医学界面临的最困难且最重要的挑战之一。越来越多的证据表明,减肥手术是实现显著且可持续体重减轻的唯一可靠方法;然而,关于青少年和成人的最佳手术方式的争论仍在继续。尽管大多数美国成人减肥外科医生更倾向于胃旁路手术,但我们机构已证明,在成人和青少年中,使用腹腔镜可调节胃束带术(LAGB)能实现同等程度的体重减轻,且发病率显著更低。本分析是对我们最初73例患者结果的更新,包括合并症的解决情况和依从性数据。

方法

自2001年9月起,所有在我们机构接受LAGB手术的13至17岁青少年均被纳入我们前瞻性收集的数据库并接受审查。术前收集的数据包括年龄、性别、种族、体重指数(BMI)和合并症情况。术后记录的数据包括住院时间、手术发病率、再次手术需求、超重减轻百分比(%EWL)以及每隔3个月的BMI;任何合并症的状况,以及术后就诊次数和束带调整次数。

结果

自2001年9月以来,73例13至17岁(平均年龄15.8±1.2岁)的青少年在我们机构接受了LAGB手术。其中,54例为女性,19例为男性。术前平均体重为298磅,BMI为48kg/m²。术后6个月、1年和2年的%EWL分别为35%±16%、57%±23%和61%±27%。1例患者因束带滑脱进行束带更换的再次手术后发生胃穿孔。另有1例患者因束带滑脱后出现限制不耐受而要求移除束带。共有6例患者发生束带滑脱,3例患者出现有症状的食管裂孔疝。营养并发症包括13例患者无症状性缺铁,4例患者无症状性维生素D缺乏,14例患者有轻度主观性脱发。在进入我们经美国食品药品监督管理局批准的研究并完成1年随访的21例患者中,共识别出51种合并症。其中,35种(68.5%)在1年后完全缓解;9种(17.5%)有所改善;5种(10%)无变化;2种(4%)加重。在1年多前接受手术的50例初始患者中,2例患者居住在离我们机构很远的地方,束带维护在当地进行,因此这2例患者被排除在分析之外。第一年有2例患者失访,第二年有3例患者失访,总体依从率至少为89.5%。第一年的平均门诊就诊次数为10±3次,平均调整次数为6±2次。

结论

腹腔镜可调节胃束带术仍然是治疗病态肥胖儿科患者的一种有吸引力的治疗策略,在1年和2年随访时%EWL均超过55%,与胃旁路手术相比发病率极低。此外,与LAGB相关的体重减轻能显著缓解或改善合并症。尽管患者需要频繁门诊就诊和进行束带调整,但青少年完全有能力做到这一点,不依从不应成为劝阻青少年接受LAGB手术的理由。在我们看来,它仍然是病态肥胖儿科患者最佳的手术选择。

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