Martini A, Massa M, De Benedetti F, Viola S, Neirotti G, Burgio R G
Clinica Pediatrica, University of Pavia, Italy.
J Rheumatol. 1990 Jul;17(7):932-5.
We investigated the levels of circulating CD5+ B cells in 43 patients with seronegative, HLA-B27 negative juvenile arthritis, 7 patients with juvenile dermatomyositis (DM) and 16 children with systemic lupus erythematosus (SLE). We found that CD5+ B cell levels were high in juvenile arthritis (p less than 0.01), normal in juvenile DM and decreased in SLE (p less than 0.01) compared to 33 age matched controls. In juvenile arthritis, the increase of CD5+ B cells appeared to be independent of discuss activity and was present in all the onset types except in a subset of patient with late onset pauciarthritis.
我们调查了43例血清阴性、HLA - B27阴性的幼年型关节炎患者、7例幼年皮肌炎（DM）患者和16例系统性红斑狼疮（SLE）患儿的循环CD5⁺ B细胞水平。我们发现，与33名年龄匹配的对照相比，幼年型关节炎患者的CD5⁺ B细胞水平较高（p小于0.01），幼年DM患者的水平正常，SLE患者的水平降低（p小于0.01）。在幼年型关节炎中，CD5⁺ B细胞的增加似乎与疾病活动无关，并且除了少数晚发性少关节炎患者外，在所有发病类型中均存在。
