Smith H R, Olson R R
Rheumatology Section, Boston Veterans Administration Medical Center, MA.
J Rheumatol. 1990 Jun;17(6):833-5.
B lymphocytes which express the CD5 antigen on their cell surface have the ability to produce autoantibodies in vitro. We describe 2 patients, one with systemic lupus erythematosus and another with rheumatoid arthritis, whose percentages of peripheral blood CD5+ B lymphocytes were dramatically increased to 68 and 100%, respectively. A reduction of this subpopulation of B cells was associated with clinical improvement after therapy. This association suggests a relationship between CD5+ B cells and autoimmune disease activity.
细胞表面表达CD5抗原的B淋巴细胞在体外具有产生自身抗体的能力。我们描述了2例患者，1例患有系统性红斑狼疮，另1例患有类风湿关节炎，他们外周血CD5+B淋巴细胞的百分比分别显著增加至68%和100%。治疗后，B细胞这一亚群数量的减少与临床症状改善相关。这种关联提示CD5+B细胞与自身免疫性疾病活动之间存在联系。
