Messent E A, Ward R J, Tonkin C J, Buckland-Wright C
Department of Applied Clinical Anatomy, King's College London, School of Medicine, Guy's Hospital Campus, London, UK.
Osteoarthritis Cartilage. 2006 Dec;14(12):1302-5. doi: 10.1016/j.joca.2006.07.012. Epub 2006 Sep 20.
To compare the sensitivity of standard and macro-radiography for quantifying cancellous bone differences between subjects with and without medial compartment knee osteoarthritis (OA).
Patients with medial compartment knee OA (n=24) and non-OA reference subjects (n=10) had a standard and a macro-radiograph (x4 magnification) of one knee. Fractal Signature Analysis (FSA), a computerised image analysis technique, measured differences in cancellous bone structure between OA and non-OA tibiae in all radiographs.
Compared to non-OA, FSA of vertical trabeculae in macro-radiographs increased significantly (P<0.05) in the OA group at several trabecular widths (0.30-0.60mm, 0.7 mm, 0.98-1.14 mm) and in standard radiographs at a single trabecular width (0.48 mm).
Compared to standard radiography, increased spatial resolution of macro-radiography allowed greater detection of trabecular bone differences between OA and non-OA knees. Nonetheless, difference was also detected in standard radiographs.
比较标准X线摄影和放大X线摄影对量化有和没有膝关节内侧间室骨关节炎（OA）的受试者之间松质骨差异的敏感性。
膝关节内侧间室OA患者（n = 24）和非OA对照受试者（n = 10）对一侧膝关节进行标准X线摄影和放大X线摄影（放大4倍）。分形特征分析（FSA）是一种计算机图像分析技术，用于测量所有X线片中OA和非OA胫骨之间松质骨结构的差异。
与非OA相比，在几个小梁宽度（0.30 - 0.60mm、0.7mm、0.98 - 1.14mm）下，OA组放大X线片中垂直小梁的FSA显著增加（P < 0.05），在标准X线片中单一小梁宽度（0.48mm）下也显著增加。
与标准X线摄影相比，放大X线摄影提高的空间分辨率能够更有效地检测OA和非OA膝关节之间的小梁骨差异。尽管如此，在标准X线片中也检测到了差异。
