人类基因组中的大脑进化与独特性。
Brain evolution and uniqueness in the human genome.
作者信息
Amadio Jordan P, Walsh Christopher A
机构信息
Division of Genetics, Children's Hospital Boston, Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, and Broad Institute of MIT and Harvard, Boston, MA 02115, USA.
出版信息
Cell. 2006 Sep 22;126(6):1033-5. doi: 10.1016/j.cell.2006.09.007.
Despite an ever-expanding database of sequenced mammalian genomes to be mined for clues, the emergence of the unique human brain remains an evolutionary enigma. In their new study, trawl the human genome and those of other mammals in search of short conserved DNA elements that show extremely rapid evolution only in humans. As they report in a recent issue of Nature, their scan yielded a gene for a novel noncoding RNA that adopts a human-specific structure and may regulate neurodevelopment.
尽管有一个不断扩大的已测序哺乳动物基因组数据库可供挖掘线索，但独特的人类大脑的出现仍然是一个进化之谜。在他们的新研究中，他们在人类基因组和其他哺乳动物基因组中搜寻短的保守DNA元件，这些元件仅在人类中显示出极快的进化速度。正如他们在最近一期《自然》杂志上所报道的，他们的扫描发现了一种新型非编码RNA的基因，该基因具有人类特有的结构，可能调控神经发育。
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