Rabelo-Santos Silvia Helena, Villa Luísa Lina, Derchain Sophie Françoise, Ferreira Silvaneide, Sarian Luis Otávio Zanatta, Angelo-Andrade Liliana Aparecida Lucci, do Amaral Westin Maria Cristina, Zeferino Luiz Carlos
School of Pharmacy, Federal University of Goiás, UFG, Goiânia, GO, Brazil.
Int J Gynecol Pathol. 2006 Oct;25(4):393-7. doi: 10.1097/01.pgp.0000215302.17029.0c.
Human papillomavirus (HPV) genotypes cannot fully explain the histological diagnosis of women with glandular abnormalities detected by cervical smear. Thus, this study was designed to analyze the distribution of HPV-16 and HPV-18 variants in women referred because of atypical glandular cells and adenocarcinoma in situ in their cervical smears and its association with histological results. Twenty-four women with HPV-16 and 6 with HPV-18, selected from 160 women with cervical smears suggestive of glandular abnormalities, were included. Histological results showed cervicitis (1 case), squamous neoplasia (18 cases), glandular neoplasia (7 cases), and glandular neoplasia associated with a squamous component (4 cases). Among the 24 cases presenting HPV-16, the European variant was detected in 15 (62%) and the Asian American in 9 (38%). Among the 15 cases associated with the European variant, 14 (93%) presented squamous neoplasia and 1 (7%) invasive adenocarcinoma. Asian-American HPV-16 variants were significantly associated with histological diagnosis of glandular neoplasia alone (odds ratio, 9.3 [1.4-60.2]) or associated with squamous neoplasia (odds ratio, 18.7 [1.5-232.3]). Adenocarcinomas were detected in 4 of 6 HPV-18-positive cases, being 2 cases had the European variant, 1 had the Asian Amerindian variant, and 1 had the African variant. The association of HPV-16 with squamous or glandular neoplasia is explained by its variants. In this study, squamous neoplasia was related to the European variant of HPV-16, whereas glandular neoplasia was related to the Asian-American variant. Glandular neoplasia is associated with HPV-18, but the results of our analysis of its variants were inconclusive.
人乳头瘤病毒（HPV）基因型无法完全解释宫颈涂片检查发现有腺体异常的女性的组织学诊断结果。因此，本研究旨在分析因宫颈涂片出现非典型腺细胞和原位腺癌而转诊的女性中HPV - 16和HPV - 18变异体的分布情况及其与组织学结果的关联。从160例宫颈涂片提示有腺体异常的女性中选取了24例HPV - 16阳性和6例HPV - 18阳性的女性。组织学结果显示为宫颈炎（1例）、鳞状上皮瘤变（18例）、腺体瘤变（7例）以及伴有鳞状成分的腺体瘤变（4例）。在呈现HPV - 16的24例病例中，检测到欧洲变异体的有15例（62%），亚美变异体的有9例（38%）。在与欧洲变异体相关的15例病例中，14例（93%）为鳞状上皮瘤变，1例（7%）为浸润性腺癌。亚美HPV - 16变异体与单纯的腺体瘤变组织学诊断（比值比，9.3 [1.4 - 60.2]）或与鳞状上皮瘤变相关（比值比，18.7 [1.5 - 232.3]）显著相关。在6例HPV - 18阳性病例中有4例检测到腺癌，其中2例为欧洲变异体，1例为亚美印第安变异体，1例为非洲变异体。HPV - 16与鳞状或腺体瘤变的关联可由其变异体来解释。在本研究中，鳞状上皮瘤变与HPV - 16的欧洲变异体相关，而腺体瘤变与亚美变异体相关。腺体瘤变与HPV - 18相关，但我们对其变异体的分析结果尚无定论。
