哇巴因对儿茶酚胺分泌及细胞内钾浓度的影响。
The effect of ouabain on the secretion of catecholamines and on the intracellular concentration of potassium.
作者信息
Banks P
出版信息
J Physiol. 1967 Dec;193(3):631-7. doi: 10.1113/jphysiol.1967.sp008383.
Abstract
- Perfusion of bovine adrenal glands with 0.1 mM ouabain is accompanied by a doubling of the spontaneous rate of release of catecholamines and by a 66% increase in the response to stimulation with carbamylcholine.2. Perfusion with ouabain (0.1 mM) reduces the intracellular content of potassium from 106 to 63 mM.3. The effect of ouabain on catecholamine secretion is dependent upon the presence of Ca(2+) ions in contrast to the effect upon the potassium content which is not dependent upon the presence of calcium.4. Ouabain has no effect on the release of catecholamines from isolated chromaffin granules both in the presence and absence of Ca(2+) ions.5. A possible relationship between the secretion of catecholamines and the concentration gradient of potassium across the cell membrane is discussed.
摘要
用0.1 mM哇巴因灌注牛肾上腺，伴随着儿茶酚胺自发释放速率加倍，以及对氨甲酰胆碱刺激的反应增加66%。
用哇巴因（0.1 mM）灌注可使细胞内钾含量从106 mM降至63 mM。
哇巴因对儿茶酚胺分泌的影响取决于Ca(2+)离子的存在，而对钾含量的影响则不依赖于钙的存在。
无论有无Ca(2+)离子，哇巴因对分离的嗜铬颗粒中儿茶酚胺的释放均无影响。
讨论了儿茶酚胺分泌与跨细胞膜钾浓度梯度之间的可能关系。
相似文献
1
The effect of ouabain on the secretion of catecholamines and on the intracellular concentration of potassium.哇巴因对儿茶酚胺分泌及细胞内钾浓度的影响。
J Physiol. 1967 Dec;193(3):631-7. doi: 10.1113/jphysiol.1967.sp008383.
2
Facilitation of secretion of catecholamines from rat and guinea-pig adrenal glands in potassium-free medium or after ouabain.在无钾培养基中或哇巴因处理后促进大鼠和豚鼠肾上腺分泌儿茶酚胺。
J Physiol. 1981;313:481-98. doi: 10.1113/jphysiol.1981.sp013677.
3
Effects of Bay K 8644 on cat adrenal catecholamine secretory responses to A23187 or ouabain.Bay K 8644对猫肾上腺儿茶酚胺分泌对A23187或哇巴因反应的影响。
Br J Pharmacol. 1986 Aug;88(4):757-65. doi: 10.1111/j.1476-5381.1986.tb16248.x.
4
On the release of catecholamines and dopamine-beta-hydroxylase evoked by ouabain in the perfused cat adrenal gland.哇巴因诱发灌注猫肾上腺释放儿茶酚胺和多巴胺-β-羟化酶的研究
Br J Pharmacol. 1980 Mar;68(3):571-83. doi: 10.1111/j.1476-5381.1980.tb14573.x.
5
Correlation between catecholamine secretion from bovine isolated chromaffin cells and [3H]-ouabain binding to plasma membranes.牛离体嗜铬细胞儿茶酚胺分泌与[3H]-哇巴因结合到质膜之间的相关性。
Br J Pharmacol. 1981 Jan;72(1):31-40. doi: 10.1111/j.1476-5381.1981.tb09101.x.
6
The key role of sodium in the ouabain-mediated potentiation of potassium-evoked catecholamine release in cat adrenal glands.钠在哇巴因介导的猫肾上腺中钾诱发的儿茶酚胺释放增强作用中的关键作用。
Br J Pharmacol. 1989 Oct;98(2):455-62. doi: 10.1111/j.1476-5381.1989.tb12618.x.
7
Sodium ions and the secretion of catecholamines.钠离子与儿茶酚胺的分泌
J Physiol. 1969 Feb;200(3):797-805. doi: 10.1113/jphysiol.1969.sp008722.
8
Ionic and metabolic requirements for stimulation of secretion by ouabain in bovine adrenal medullary cells.哇巴因刺激牛肾上腺髓质细胞分泌的离子和代谢需求。
Mol Pharmacol. 1983 May;23(3):671-80.
9
The effect of sodium and calcium ions on the release of catecholamines from the adrenal medulla: sodium deprivation induces release by exocytosis in the absence of extracellular calcium.钠和钙离子对肾上腺髓质儿茶酚胺释放的影响：缺钠在细胞外钙缺乏的情况下通过胞吐作用诱导释放。
J Physiol. 1974 Feb;236(3):681-705. doi: 10.1113/jphysiol.1974.sp010460.
10
Experimental evidence for calcium independent catecholamine secretion from the bovine adrenal medulla.牛肾上腺髓质中钙非依赖性儿茶酚胺分泌的实验证据。
J Pharmacol Exp Ther. 1975 May;193(2):513-22.
引用本文的文献
1
Effect of ouabain on calcium signaling in rodent brain: A systematic review of studies.哇巴因对啮齿动物大脑钙信号的影响：研究的系统评价
Front Pharmacol. 2022 Aug 29;13:916312. doi: 10.3389/fphar.2022.916312. eCollection 2022.
2
Brain soluble fractions which modulate Na+, K+-ATPase activity likewise modify muscarinic receptor.调节钠钾ATP酶活性的脑可溶性组分同样会修饰毒蕈碱受体。
Neurochem Res. 1999 Nov;24(11):1417-22. doi: 10.1023/a:1022536824190.
3
Studies on secretion of catecholamine evoked by caffeine from the isolated perfused rat adrenal gland.咖啡因诱发离体灌注大鼠肾上腺分泌儿茶酚胺的研究。
Arch Pharm Res. 1991 Mar;14(1):55-67. doi: 10.1007/BF02857816.
4
Potentiation of K+-evoked catecholamine release in the cat adrenal gland treated with ouabain.哇巴因处理的猫肾上腺中钾离子诱发的儿茶酚胺释放的增强作用
Br J Pharmacol. 1981 Nov;74(3):673-80. doi: 10.1111/j.1476-5381.1981.tb10478.x.
5
Correlation between catecholamine release and sodium pump inhibition in the perfused adrenal gland of the cat.猫灌注肾上腺中儿茶酚胺释放与钠泵抑制之间的相关性。
Br J Pharmacol. 1981 Nov;74(3):665-72. doi: 10.1111/j.1476-5381.1981.tb10477.x.
6
Effects of the cardiotonic drug ARL-115 on the release of noradrenaline from the cat atrium, the binding of 3H-ouabain to plasma membranes and the movements of calcium in mitochondria.强心药ARL-115对猫心房去甲肾上腺素释放、3H-哇巴因与质膜结合以及线粒体钙转运的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1982 Sep;320(3):255-9. doi: 10.1007/BF00510137.
7
Studies on the mechanism of renin release from rat kidney slices: calcium, sodium and metabolic inhibition.大鼠肾切片肾素释放机制的研究：钙、钠及代谢抑制
J Physiol. 1980 Jul;304:99-108. doi: 10.1113/jphysiol.1980.sp013312.
8
On the release of catecholamines and dopamine-beta-hydroxylase evoked by ouabain in the perfused cat adrenal gland.哇巴因诱发灌注猫肾上腺释放儿茶酚胺和多巴胺-β-羟化酶的研究
Br J Pharmacol. 1980 Mar;68(3):571-83. doi: 10.1111/j.1476-5381.1980.tb14573.x.
9
Sodium-potassium ATPase inhibition potentiates compound 48/80-induced histamine secretion from mast cells.钠钾ATP酶抑制作用增强了化合物48/80诱导的肥大细胞组胺分泌。
Br J Pharmacol. 1984 Jun;82(2):423-30. doi: 10.1111/j.1476-5381.1984.tb10777.x.
10
Correlation between catecholamine secretion from bovine isolated chromaffin cells and [3H]-ouabain binding to plasma membranes.牛离体嗜铬细胞儿茶酚胺分泌与[3H]-哇巴因结合到质膜之间的相关性。
Br J Pharmacol. 1981 Jan;72(1):31-40. doi: 10.1111/j.1476-5381.1981.tb09101.x.
本文引用的文献
1
Membrane potential measurement in cells of the adrenal gland.肾上腺细胞的膜电位测量。
J Physiol. 1967 Mar;189(1):139-48. doi: 10.1113/jphysiol.1967.sp008159.
2
[The influence of calcium on catecholamine liberation].[钙对儿茶酚胺释放的影响]
Experientia. 1962 Mar 15;18:138-40. doi: 10.1007/BF02153862.
3
The role of calcium in the secretory response of the adrenal medulla to acetylcholine.钙在肾上腺髓质对乙酰胆碱分泌反应中的作用。
J Physiol. 1961 Nov;159(1):40-57. doi: 10.1113/jphysiol.1961.sp006791.
4
On the mode of action of acetylcholine in evoking adrenal medullary secretion: increased uptake of calcium during the secretory response.关于乙酰胆碱诱发肾上腺髓质分泌的作用方式：分泌反应期间钙摄取增加。
J Physiol. 1962 Aug;162(3):385-92. doi: 10.1113/jphysiol.1962.sp006940.
5
A lithium internal-standard flame photometer.锂内标火焰光度计。
Biochem J. 1958 Jun;69(2):236-8. doi: 10.1042/bj0690236.
6
Changes in end-plate activity produced by presynaptic polarization.突触前极化引起的终板活动变化。
J Physiol. 1954 Jun 28;124(3):586-604. doi: 10.1113/jphysiol.1954.sp005131.
7
The sodium pump and insulin secretion.钠泵与胰岛素分泌
Biochim Biophys Acta. 1967 May 2;135(2):375-7. doi: 10.1016/0005-2736(67)90136-8.
8
The release of adenosine triphosphate catabolites during the secretion of catecholamines by bovine adrenal medulla.牛肾上腺髓质分泌儿茶酚胺过程中三磷酸腺苷分解代谢产物的释放。
Biochem J. 1966 Nov;101(2):536-41. doi: 10.1042/bj1010536.
9
Tetrodotoxin and neuromuscular transmission.河豚毒素与神经肌肉传递
Proc R Soc Lond B Biol Sci. 1967 Jan 31;167(1006):8-22. doi: 10.1098/rspb.1967.0010.
10
Effects of acetylcholine and other medullary secretagogues and antagonists on the membrane potential of adrenal chromaffin cells: an analysis employing techniques of tissue culture.乙酰胆碱及其他延髓促分泌素和拮抗剂对肾上腺嗜铬细胞膜电位的影响：一项运用组织培养技术的分析
J Physiol. 1967 Jan;188(1):107-20. doi: 10.1113/jphysiol.1967.sp008127.
Zotero 插件