钠离子与儿茶酚胺的分泌
Sodium ions and the secretion of catecholamines.
作者信息
Banks P, Biggins R, Bishop R, Christian B, Currie N
出版信息
J Physiol. 1969 Feb;200(3):797-805. doi: 10.1113/jphysiol.1969.sp008722.
Abstract
- Perfusion of bovine adrenal glands with a potassium-free Tyrode solution results in an increased spontaneous release of catecholamines and an increased response to stimulation with carbamylcholine.2. Perfusion with a Tyrode solution containing 70 mM-KCl causes a marked secretion of catecholamines and a subsequent inhibition of secretion in response to stimulation with carbamylcholine.3. Perfusion with sodium-free media abolishes or severely reduces the secretory response of the gland to carbamylcholine and to 70 mM-KCl although the basal secretion shows an initial rise.4. Perfusion with sodium-deficient media permits some retention of the secretory response.5. A possible role for intracellular sodium ions in the secretion of catecholamines is discussed.
摘要
用无钾的台氏液灌注牛肾上腺会导致儿茶酚胺的自发释放增加，以及对氨甲酰胆碱刺激的反应增强。
用含70 mM - KCl的台氏液灌注会引起儿茶酚胺的大量分泌，随后对氨甲酰胆碱刺激的分泌产生抑制。
用无钠培养基灌注会消除或严重降低腺体对氨甲酰胆碱和70 mM - KCl的分泌反应，尽管基础分泌最初会增加。
用缺钠培养基灌注可使分泌反应部分得以保留。
讨论了细胞内钠离子在儿茶酚胺分泌中的可能作用。
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