Ersev A, Ersev D, Turkeri L, Ilker Y, Simsek F, Kullu S, Akdas A
Department of Pathology, Marmara University School of Medicine, Istanbul, Turkey.
Prog Clin Biol Res. 1990;357:129-34.
This study examines the relationship between the presence of prostatic acid phosphatase (PAP) and prostate specific antigen (PSA) in tissue, the serum PAP and PSA levels and tumour grade in prostatic adenocarcinoma. Thirty-three tumours were studied by the indirect immunoperoxidase method for PAP and PSA production. Thirty-one of them were stained positive for both markers. The remaining two which previous histopathological studies suggested were transitional cell carcinoma, stained negative. In primary tumours there was a weak trend for poor immunoreactivity in high grade neoplasms but the correlation was not significant. The elevated serum PAP and PSA levels did not correlate with the intensity of staining in the tissue.
本研究探讨前列腺腺癌组织中前列腺酸性磷酸酶（PAP）和前列腺特异性抗原（PSA）的存在、血清PAP和PSA水平与肿瘤分级之间的关系。采用间接免疫过氧化物酶法对33个肿瘤进行PAP和PSA生成研究。其中31个肿瘤两种标志物染色均呈阳性。其余两个经先前组织病理学研究提示为移行细胞癌，染色呈阴性。在原发性肿瘤中，高级别肿瘤免疫反应性较差有微弱趋势，但相关性不显著。血清PAP和PSA水平升高与组织中的染色强度无关。
