Brawer M K
Department of Urology, University of Washington, Seattle.
Urol Clin North Am. 1990 Nov;17(4):759-68.
Acid phosphatase and prostate-specific antigen are extremely useful markers for the management of patients with prostatic carcinoma. Prostatic acid phosphatase, because of its relatively low sensitivity and specificity, as well as analyte instability and diurnal variability, is unsuitable for prostate cancer screening. Improved performance characteristics, stability, the lesser diurnal variation, and the association of elevated prostate-specific antigen with prostatic intraepithelial neoplasia make prostate-specific antigen possibly a better candidate for early detection of this common malignancy. Further investigations in this area are clearly indicated before we can recommend screening with prostate-specific antigen.
酸性磷酸酶和前列腺特异性抗原是前列腺癌患者管理中极为有用的标志物。前列腺酸性磷酸酶因其相对较低的敏感性和特异性，以及分析物的不稳定性和昼夜变化，不适用于前列腺癌筛查。前列腺特异性抗原具有改善的性能特征、稳定性、较小的昼夜变化，以及与前列腺上皮内瘤变相关的升高水平，使其可能成为早期检测这种常见恶性肿瘤的更好候选指标。在我们能够推荐使用前列腺特异性抗原进行筛查之前，显然需要在该领域进行进一步的研究。
