Abdurrahman M B, Elidrissy A T, Shipkey F H, al Rasheed S, al Mugeiren M
Department of Paediatrics, College of Medicine, Riyadh, Saudi Arabia.
Ann Trop Paediatr. 1990;10(2):125-32. doi: 10.1080/02724936.1990.11747419.
The clinicopathological features are described in 119 Arab children in Saudi Arabia with the nephrotic syndrome. The clinical and laboratory data are similar to those described in other parts of the world. However, mesangial proliferative glomerulonephritis (MesPGN) was found in 21 of 66 biopsies (31.8%), giving a frequency of 17.6% of all children with the nephrotic syndrome. Minimal-change nephrotic syndrome (MCNS) was diagnosed in 17 biopsies (25.8%) and in 58 patients (48.7%). Onset of the nephrotic syndrome was at less than 1 year of age in 17 patients (14.3%). Seven children had 11 episodes of peritonitis. Seven children had positive hepatitis B surface antigen (HBsAg) in their serum: renal biopsy carried out on four of them showed membranous glomerulonephritis (MGN) in three, and four of the seven patients developed end-stage renal disease (ESRD). There were nine deaths, all in patients with end-stage renal disease: six of the deaths occurred in infants. The pattern of childhood nephrotic syndrome in Saudi Arabia is different from the pattern in tropical countries.
本文描述了沙特阿拉伯119例患肾病综合征的阿拉伯儿童的临床病理特征。其临床和实验室数据与世界其他地区所描述的相似。然而，在66例活检病例中有21例（31.8%）发现系膜增生性肾小球肾炎（MesPGN），在所有肾病综合征患儿中所占比例为17.6%。17例活检病例（25.8%）以及58例患者（48.7%）被诊断为微小病变肾病综合征（MCNS）。17例患者（14.3%）在1岁以内出现肾病综合征。7名儿童发生了11次腹膜炎。7名儿童血清乙肝表面抗原（HBsAg）呈阳性：其中4例进行了肾活检，3例显示为膜性肾小球肾炎（MGN），7例患者中有4例发展为终末期肾病（ESRD）。有9例死亡，均为终末期肾病患者：其中6例死亡发生在婴儿。沙特阿拉伯儿童肾病综合征的模式与热带国家不同。
