临床和实验室特征无法区分系膜增生性肾病和微小病变型肾病综合征。

Failure of clinical and laboratory characteristics to differentiate mesangial proliferative from minimal-change nephrotic syndrome.

作者信息

Abdurrahman M B, Elidrissy A T, Mahmoud K, al Rasheed S, al Mugeirin M

机构信息

Department of Paediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

出版信息

Acta Paediatr. 1993 Jun-Jul;82(6-7):579-81. doi: 10.1111/j.1651-2227.1993.tb12758.x.

DOI:10.1111/j.1651-2227.1993.tb12758.x

PMID:8338994

Abstract

Twelve clinical and laboratory characteristics of nephrotic syndrome were compared in 24 children with biopsy-proven mesangial proliferative glomerulonephritis (MesPGN) and 17 children with biopsy-proven minimal-change nephropathy (MCNS). The objective of the study was to determine if these characteristics alone, without renal biopsy, could be used to differentiate the two histopathologic entities. Sex, urinary protein level and IgM immunofluorescence were found to be significantly different in the two groups. Discriminant analysis produced two formulae which gave a discriminant rate of 79% for MesPGN and 76% for MCNS. We conclude that the clinical and laboratory characteristics studied could not differentiate MesPGN from MCNS.

摘要

对24例经活检证实为系膜增生性肾小球肾炎（MesPGN）的儿童和17例经活检证实为微小病变肾病（MCNS）的儿童的肾病综合征的12项临床和实验室特征进行了比较。本研究的目的是确定在不进行肾活检的情况下，这些特征是否可用于区分这两种组织病理学实体。发现两组在性别、尿蛋白水平和IgM免疫荧光方面存在显著差异。判别分析得出两个公式，MesPGN的判别率为79%，MCNS的判别率为76%。我们得出结论，所研究的临床和实验室特征无法区分MesPGN和MCNS。