Haffejee I E, Moosa A
Department of Paediatrics and Child Health, Faculty of Medicine, University of Natal, South Africa.
Ann Trop Paediatr. 1990;10(2):173-8. doi: 10.1080/02724936.1990.11747426.
Despite the well-recognized association between rotavirus (RV) and infantile diarrhoeal disease, a few studies have shown that the isolation rate of RV from the faeces of non-diarrhoeal patients can be high, suggesting that the finding of RV in the stools of individual gastro-enteritis (GE) patients need not necessarily denote an aetiological relationship. A prospective study of rotavirus serology and stool excretion was carried out in a group of non-diarrhoeal paediatric patients. A positive ELISA for RV antigen was found in 13.3% children, which compared favourably with an asymptomatic RV-excretion rate of 16.2% found in normal subjects in the community, but differed significantly from the 54.6% RV-excretion rate found in hospitalized GE patients. This confirms that RV is an important enteropathogen. Furthermore, approximately half of the non-diarrhoeal infants acquired nosocomial RV infections in hospital, most of these being asymptomatic. One-sixth of asymptomatic RV excretors showed evidence of prior exposure to rotavirus.
尽管轮状病毒（RV）与婴儿腹泻病之间的关联已得到广泛认可，但一些研究表明，从无腹泻患者粪便中分离出RV的比率可能很高，这表明在个别胃肠炎（GE）患者粪便中发现RV不一定意味着存在病因学关系。对一组无腹泻的儿科患者进行了轮状病毒血清学和粪便排泄的前瞻性研究。13.3%的儿童RV抗原ELISA检测呈阳性，这与社区正常人群中16.2%的无症状RV排泄率相当，但与住院GE患者中54.6%的RV排泄率有显著差异。这证实了RV是一种重要的肠道病原体。此外，大约一半的无腹泻婴儿在医院获得了医院内RV感染，其中大多数无症状。六分之一的无症状RV排泄者有先前接触轮状病毒的证据。
