Krämer S, Bischoff S C
Lehrstuhl für Ernährungsmedizin/Prävention, Universität Hohenheim.
MMW Fortschr Med. 2006 Aug 31;148(35-36):28-30. doi: 10.1007/BF03364716.
One of the major problems associated with the use of antibiotics is the occurrence of antibiotic-related diarrhea. Although most such cases of diarrhea are harmless, in individual cases it may lead on to fulminant colitis. In 10-20% of the patients, the causal factor is infection with Clostridium difficile, which multiplies unhindered in patients on antibiotics. In the meantime, controlled, randomized studies have shown that probiotics can exercise a preventive effect in antibiotic-related diarrhea. The administration of Saccharomyces boulardii or Lactobacillus rhamnosus GG reduces the relative risk of an antibiotic-related diarrhea developing by 0.5. The data are more uniform in children than in adults.
使用抗生素的一个主要问题是出现与抗生素相关的腹泻。虽然大多数此类腹泻病例无害，但个别情况下可能会发展为暴发性结肠炎。在10%至20%的患者中，病因是艰难梭菌感染，这种细菌在使用抗生素的患者体内不受阻碍地繁殖。与此同时，对照随机研究表明，益生菌对抗生素相关性腹泻有预防作用。服用布拉酵母菌或鼠李糖乳杆菌GG可使抗生素相关性腹泻发生的相对风险降低0.5。儿童的数据比成人的数据更一致。
