Mazik Monika, König Alexander
Institut für Organische Chemie der Technischen Universität Braunschweig, Hagenring 30, 38106 Braunschweig, Germany.
J Org Chem. 2006 Sep 29;71(20):7854-7. doi: 10.1021/jo0610309.
Biphenyl-based receptor 1, incorporating four heterocyclic recognition units, was synthesized, and its binding properties toward neutral sugars were determined. Receptor 1 is a representative of a new series of acyclic carbohydrate-binding receptors, which were designed to recognize disaccharides. The compound 1 has been established as a highly effective receptor for dodecyl beta-D-maltoside, showing successive 1:1 and 2:1 receptor/substrate complexation behavior toward the disaccharide. Both hydrogen bonding and interactions of the sugar CH's with the aromatic units of the receptor contribute to the stabilization of the receptor-maltoside complexes.
合成了包含四个杂环识别单元的联苯类受体1，并测定了其对中性糖的结合特性。受体1是一系列新型无环碳水化合物结合受体的代表，这些受体旨在识别二糖。化合物1已被确立为十二烷基β-D-麦芽糖苷的高效受体，对该二糖呈现出连续的1:1和2:1受体/底物络合行为。氢键以及糖的CH基团与受体芳香单元的相互作用都有助于受体-麦芽糖苷络合物的稳定。
