Jin Jie, Ye Wei-jiang, Huang Jin-song, Yu Zhe, Yu Hai-yan
Hangzhou Sixth Peopleos Hospital, Hangzhou 310014, China.
Zhonghua Gan Zang Bing Za Zhi. 2006 Sep;14(9):652-4.
To explore the clinical effects of combined non-biological artificial liver in the treatment of late stage chronic severe hepatitis and especially to observe their effects on hepatic encephalopathy, hepatorenal syndrome and disturbance of electrolytes.
103 chronic severe hepatitis patients were treated with the same medical measures, including plasma exchange. Among them, 63 patients were also treated with combinations of non-biological artificial liver (treatment group), and the other 40 patients served as controls (control group). The efficacy of the treatments and survival rates of the two groups were compared.
In the treatment group, the rate of regaining normal consciousness was 72.7%, the rate of electrolyte disorder being rectified was 89.5%, the rate of restoring renal function was 66.7% and the total survival rate was 47.6%. In comparison, in the control group the rate of regaining normal consciousness was 16.7%, the rate of electrolyte disorder being rectified was 42.3%, none of their renal functions were restored and the total survival rate was 22.5%. The differences between the two groups were significant (chi2=6.56, P less than 0.05).
With other medical treatment, combined non-biological artificial liver can improve the survival rate of severe hepatitis patients.
探讨非生物型人工肝联合治疗晚期慢性重型肝炎的临床疗效，重点观察其对肝性脑病、肝肾综合征及电解质紊乱的影响。
103例慢性重型肝炎患者均采用包括血浆置换在内的相同内科治疗措施。其中63例患者同时接受非生物型人工肝联合治疗（治疗组），另外40例患者作为对照组。比较两组的治疗效果及生存率。
治疗组意识恢复正常率为72.7%，电解质紊乱纠正率为89.5%，肾功能恢复率为66.7%，总生存率为47.6%。相比之下，对照组意识恢复正常率为16.7%，电解质紊乱纠正率为42.3%，肾功能均未恢复，总生存率为22.5%。两组差异有显著性（χ2 = 6.56，P < 0.05）。
非生物型人工肝联合其他内科治疗可提高重型肝炎患者的生存率。
