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一名2岁男性的银杏果中毒病例。

Ginkgo nut intoxication in a 2-year-old male.

作者信息

Hasegawa Shunji, Oda Yasutaka, Ichiyama Takashi, Hori Yasushi, Furukawa Susumu

机构信息

Department of Allergy, Yamaguchi University, School of Medicine, and Department of Hospital Pharmacy, Niigata City General Hospital, Japan.

出版信息

Pediatr Neurol. 2006 Oct;35(4):275-6. doi: 10.1016/j.pediatrneurol.2006.05.008.

DOI:10.1016/j.pediatrneurol.2006.05.008
PMID:16996402
Abstract

This report describes a case of ginkgo nut intoxication in a 2-year-old male. The patient presented with vomiting and afebrile convulsion 4 hours after eating a large number of roasted gingko nuts. There was a large volume of ginkgo nuts in his vomited matter, and on admission the concentrations of 4-O-methoxypyridoxine in his serum and urine were elevated. The patient was diagnosed as having ginkgo nut intoxication, and diazepam and pyridoxal phosphate were administered intravenously. After the treatment, his symptoms were resolved. The neurotoxicity of ginkgo nuts should be recognized by pediatricians and parents who have infants.

摘要

本报告描述了一名2岁男性银杏果中毒的病例。该患者在食用大量烤银杏果4小时后出现呕吐和无热惊厥。其呕吐物中有大量银杏果,入院时血清和尿液中4 - O - 甲氧基吡哆醇浓度升高。该患者被诊断为银杏果中毒,静脉注射了地西泮和磷酸吡哆醛。治疗后,其症状得到缓解。儿科医生和有婴儿的家长应认识到银杏果的神经毒性。

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1
Ginkgo nut intoxication in a 2-year-old male.一名2岁男性的银杏果中毒病例。
Pediatr Neurol. 2006 Oct;35(4):275-6. doi: 10.1016/j.pediatrneurol.2006.05.008.
2
Generalized convulsions after consuming a large amount of gingko nuts.食用大量银杏果后出现全身性惊厥。
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[Food Poisoning by Ginkgo Seeds through Vitamin B Depletion].[银杏种子通过消耗维生素B导致食物中毒]
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Epileptic Seizure from Ginkgo Nut Intoxication in an Adult.一名成人因白果中毒引发癫痫发作
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[Practical analysis of toxic substances useful for clinical toxicology. (4). 4-O-methylpyridoxine (MPN ; ginkotoxine)].[临床毒理学实用毒物分析。(4)。4-氧甲基吡哆醇(MPN;银杏毒素)]
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The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba.人源吡哆醛激酶,一种可能的银杏叶中白果毒素作用靶点。
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Gas chromatography-mass spectrometry analysis of 4-O-methylpyridoxine (MPN) in the serum of patients with ginkgo seed poisoning.银杏种子中毒患者血清中4-氧甲基吡哆醇(MPN)的气相色谱-质谱分析
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Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies.与新生儿癫痫性脑病和其他病理相关的维生素 B6 补救酶的先天性缺陷。
Biochimie. 2021 Apr;183:18-29. doi: 10.1016/j.biochi.2020.12.025. Epub 2021 Jan 6.
3
An Adult Case of Generalized Convulsions Caused by the Ingestion of Ginkgo biloba Seeds with Alcohol.
一例因食用银杏种子并饮酒导致全身惊厥的成人病例。
Intern Med. 2020 Jun 15;59(12):1555-1558. doi: 10.2169/internalmedicine.4196-19. Epub 2020 Mar 5.
4
Epileptic Seizure from Ginkgo Nut Intoxication in an Adult.一名成人因白果中毒引发癫痫发作
Case Rep Emerg Med. 2020 Jan 28;2020:5072954. doi: 10.1155/2020/5072954. eCollection 2020.
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Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports.银杏叶引起的毒性研究综述:从实验研究到人类病例报告
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2017 Jan 2;35(1):1-28. doi: 10.1080/10590501.2016.1278298.
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A systematic review of the reporting of adverse events associated with medical herb use among children.一项关于儿童使用草药相关不良事件报告的系统评价。
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Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs.暴露于银杏毒素的斑马鱼幼虫表现出类似癫痫发作的行为,这种行为可以通过吡哆醛-5'-磷酸、GABA 和抗癫痫药物得到缓解。
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