Azuma Fumika, Nokura Kazuya, Kako Tetsuharu, Kobayashi Daisuke, Yoshimura Teruki, Wada Keiji
Department of Neurology, Fujita Health University, Bantane Hospital, Japan.
School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan.
Intern Med. 2020 Jun 15;59(12):1555-1558. doi: 10.2169/internalmedicine.4196-19. Epub 2020 Mar 5.
A 64-year-old woman developed symptoms of vomiting and tonic-clonic convulsions 9.5 h after eating 50 roasted Ginkgo biloba seeds with 100 g of alcohol. The intravenous administration of pyridoxal phosphate effectively improved the symptoms. Blood samples were collected and stored over 35 h. The assessment of 4'-O-methylpyridoxine and vitamin B6 vitamers indicated high levels of both, but the pyridoxal phosphate levels were low during the acute stage. These results suggest that 4'-O-methylpyridoxine inhibits the transformation of vitamin B6 analogues to the active form, pyridoxal phosphate. In our case, alcohol may have extended the period until ginkgo intoxication appeared.
一名64岁女性在食用50颗炒白果并饮用100克酒精后9.5小时出现呕吐和强直性阵挛性惊厥症状。静脉注射磷酸吡哆醛有效改善了症状。采集血样并保存35小时以上。对4'-O-甲基吡哆醇和维生素B6维生素类似物的评估表明二者水平均较高，但急性期磷酸吡哆醛水平较低。这些结果表明，4'-O-甲基吡哆醇抑制维生素B6类似物转化为活性形式的磷酸吡哆醛。在我们的病例中，酒精可能延长了白果中毒出现的时间。
