Ferrantelli Flavia, Buckley Kathleen A, Rasmussen Robert A, Chalmers Alistair, Wang Tao, Li Pei-Lin, Williams Alison L, Hofmann-Lehmann Regina, Montefiori David C, Cavacini Lisa A, Katinger Hermann, Stiegler Gabriela, Anderson Daniel C, McClure Harold M, Ruprecht Ruth M
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Virology. 2007 Feb 5;358(1):69-78. doi: 10.1016/j.virol.2006.07.056. Epub 2006 Sep 25.
In a primate model of postnatal virus transmission, we have previously shown that 1 h post-exposure prophylaxis (PEP) with a triple combination of neutralizing monoclonal antibodies (nmAbs) conferred sterilizing protection to neonatal macaques against oral challenge with pathogenic simian-human immunodeficiency virus (SHIV). Here, we show that nmAbs can also partially protect SHIV-exposed newborn macaques against infection or disease, when given as 12 or 24 h PEP, respectively. This work delineates the potential and the limits of passive immunoprophylaxis with nmAbs. Even though 24 h PEP with nmAbs did not provide sterilizing immunity to neonatal monkeys, it contained viremia and protected infants from acute disease. Taken together with our results from other PEP studies, these data show that the success of passive immunization depends on the nmAb potency/dose and the time window between virus exposure and start of immunotherapy.
在一种产后病毒传播的灵长类动物模型中，我们之前已经表明，用三种中和单克隆抗体（nmAbs）联合进行暴露后1小时预防（PEP），可使新生猕猴对致病性猿猴-人类免疫缺陷病毒（SHIV）的口服攻击获得无菌免疫保护。在此，我们表明，当分别在暴露后12小时或24小时给予PEP时，nmAbs也能部分保护暴露于SHIV的新生猕猴免受感染或疾病侵害。这项工作阐明了用nmAbs进行被动免疫预防的潜力和局限性。尽管用nmAbs进行24小时PEP未给新生猴提供无菌免疫，但它抑制了病毒血症并保护婴儿免受急性疾病侵害。结合我们其他PEP研究的结果，这些数据表明被动免疫的成功取决于nmAb的效力/剂量以及病毒暴露与免疫治疗开始之间的时间窗。
Front Immunol. 2017-11-28
Proc Natl Acad Sci U S A. 2014-11-4
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