Immunology. 2014 May;142(1):46-57. doi: 10.1111/imm.12232.
The importance of Fc-mediated effector function in protective immunity to HIV-1 (hereafter referred to simply as HIV) is becoming increasingly apparent. A large of number of studies in natural infection cohorts, spanning the last 26 years, have associated Fc-mediated effector function, particularly antibody-dependent cellular cytotoxicity, with a favourable clinical course. These studies strongly suggest a role for Fc-mediated effector function in the post-infection control of viraemia. More recently, studies in both humans and non-human primates (NHPs) also implicate Fc-mediated effector function in blocking HIV acquisition. Accordingly, this review will discuss the results supporting a role of Fc-mediated effector function in both blocking acquisition and post-infection control of viraemia. Parallel studies in NHPs and humans will be compared for common themes. Context for this discussion will be provided by summarizing the temporal emergence of key host and virological events over the course of an untreated HIV infection framing where, when and how Fc-mediated effector function might be protective. A hypothesis that Fc-mediated effector function protects primarily in the early stages of both acquisition and post-infection control of viraemia will be developed.
Fc 介导的效应功能在保护性免疫 HIV-1（以下简称 HIV）中的重要性日益明显。大量的自然感染队列研究跨越了过去 26 年，将 Fc 介导的效应功能，特别是抗体依赖的细胞毒性，与有利的临床病程相关联。这些研究强烈表明 Fc 介导的效应功能在感染后控制病毒血症方面发挥了作用。最近，人类和非人类灵长类动物（NHPs）的研究也表明 Fc 介导的效应功能在阻断 HIV 获得方面发挥了作用。因此，本综述将讨论支持 Fc 介导的效应功能在阻断获得和感染后控制病毒血症方面的作用的结果。将对 NHP 和人类的平行研究进行比较，以寻找共同的主题。这一讨论的背景是总结未经治疗的 HIV 感染过程中关键宿主和病毒学事件的时间发生，确定 Fc 介导的效应功能可能具有保护作用的时间、地点和方式。将提出一个假设，即 Fc 介导的效应功能主要在获得和感染后控制病毒血症的早期阶段提供保护。
