Camarena Beatriz, Loyzaga Cristina, Aguilar Alejandro, Weissbecker Karen, Nicolini Humberto
Department of Psychiatric Genetics, National Institute of Psychiatry Ramón de la Fuente, Mexico D.F. 14370, Mexico.
Eur Neuropsychopharmacol. 2007 May-Jun;17(6-7):406-9. doi: 10.1016/j.euroneuro.2006.08.001. Epub 2006 Sep 25.
Pharmacological and neuroanatomical evidence suggest the involvement of the dopaminergic system in obsessive-compulsive disorder (OCD). Analysis of the 48-bp dopamine receptor D(4) (DRD4) gene polymorphism in a sample of 210 OCD patients and 202 healthy control subjects showed a significant association (chi(2)=27.5, df=6, p=0.0003). This difference was attributable to a lower frequency of allele 4R in OCD patients compared with the control group (chi(2)=9.33, p=0.0027). However, we did not replicate previous findings of an association between the 7R allele and OCD patients with tics. Finally, we analyzed a sub-sample of 86 OCD families. E-TDT analysis in 70 informative parents did not confirm the association observed in our case-control analysis. In conclusion, the current study cannot exclude an association between DRD4 gene and OCD in the largest sample analyzed. However, further studies will be required to confirm if the DRD4 gene is involved in the pathogenesis of this disorder.
药理学和神经解剖学证据表明多巴胺能系统与强迫症（OCD）有关。对210例强迫症患者和202例健康对照者样本进行的48碱基对多巴胺受体D(4)（DRD4）基因多态性分析显示存在显著关联（χ²=27.5，自由度=6，p=0.0003）。这种差异归因于与对照组相比，强迫症患者中4R等位基因的频率较低（χ²=9.33，p=0.0027）。然而，我们并未重复先前关于7R等位基因与伴有抽动的强迫症患者之间存在关联的研究结果。最后，我们分析了86个强迫症家庭的一个子样本。对70名信息丰富的父母进行的E-TDT分析未证实我们在病例对照分析中观察到的关联。总之，在分析的最大样本中，当前研究不能排除DRD4基因与强迫症之间的关联。然而，需要进一步研究来证实DRD4基因是否参与该疾病的发病机制。
