海胆幼虫肌肉活动的药理学控制。III. 环核苷酸的作用。
Pharmacological control of muscular activity in the sea urchin larva. III. Role of cyclic nucleotides.
作者信息
Gustafson T
机构信息
Wenner-Gren Institute, Biologihus F3, University of Stockholm, Sweden.
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1990;95(2):133-43. doi: 10.1016/0742-8413(90)90094-p.
PMID:1699701
Abstract
- The muscular activity of the sea urchin pluteus is strongly affected by dibutyryl-c-AMP, in a stimulatory or inhibitory manner depending on the concentration, the time of exposure, and the spontaneous level of activity. 2. Dibutyryl-c-GMP, like muscarinic agents and the guanylate-cyclase activators biotin and nitrite, keeps the activity low. 3. It is suggested that the effects of muscarinic agents is mediated by c-GMP, the effects of certain monoamines by c-AMP. 4. The two cyclic nucleotides appear to control the cellular influx of Ca2+ in opposite directions. They therefore interfere with the stimulatory and paralytic effects of nicotinic agents.
摘要
- 海胆长腕幼虫的肌肉活动受到二丁酰环磷腺苷（dibutyryl-c-AMP）的强烈影响，根据其浓度、暴露时间和自发活动水平，呈现出刺激或抑制作用。2. 二丁酰环磷鸟苷（dibutyryl-c-GMP），与毒蕈碱样药物以及鸟苷酸环化酶激活剂生物素和亚硝酸盐一样，会使活动保持在较低水平。3. 有人提出，毒蕈碱样药物的作用是由环磷鸟苷（c-GMP）介导的，某些单胺的作用是由环磷腺苷（c-AMP）介导的。4. 这两种环核苷酸似乎以相反的方向控制细胞对钙离子的内流。因此，它们会干扰烟碱样药物的刺激和麻痹作用。
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