海胆幼虫肌肉活动的药理学控制——IV. 单胺类和腺苷的作用。

Pharmacological control of muscular activity in the sea urchin larva--IV. Effects of monoamines and adenosine.

Gustafson T

Wenner-Gren Institute, Arrhenius Laboratories F3, University of Stockholm, Sweden.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1991;98(2-3):307-15. doi: 10.1016/0742-8413(91)90210-k.

Abstract

The muscular activity of the sea urchin pluteus is affected by catecholamines. alpha-Agonists in high concentrations bring about a strong, temporary, stimulation. 2. The stimulation by beta-agonists tends to be masked by different mechanisms. 3. Serotonin brings about a strong stimulation of long duration, even at 10(-7) M. It reactivates larvae where the activity has declined after exposure to catecholamines. A dopamine-effect at 10(-5)-5 x 10(-6) M is similar to that of serotonin. The effect of adenosine is similar to that of dc-c-AMP. 4. The action of the alpha- and beta-agonists and adenosine appears to involve an increased respectively excessive Ca2(+)-influx, directly or indirectly mediated by c-AMP. 5. It is suggested that a strong Ca2(+)-influx induces an outflux of K+ leading to hyperpolarization. Serotonin may decrease the K(+)-outflux.

摘要

海胆长腕幼虫的肌肉活动受儿茶酚胺影响。高浓度的α-激动剂会引起强烈的、暂时的刺激。2. β-激动剂的刺激往往会被不同机制掩盖。3. 血清素即使在10⁻⁷M时也会引起强烈且持续时间长的刺激。它能使在接触儿茶酚胺后活动下降的幼虫重新恢复活动。10⁻⁵ - 5×10⁻⁶M的多巴胺效应与血清素相似。腺苷的作用与双丁酰环磷腺苷酸相似。4. α-和β-激动剂以及腺苷的作用似乎分别涉及通过环磷腺苷酸直接或间接介导的Ca²⁺内流增加或过量。5. 有人提出强烈的Ca²⁺内流会诱导K⁺外流导致超极化。血清素可能会减少K⁺外流。