Raygani Asad Vaisi, Rahimi Zohreh, Kharazi Hadi, Tavilani Haidar, Pourmotabbed Tayebeh
Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Daneshgah Avenue, P.O. Box 67148, 69914 Kermanshah, Iran.
Neurosci Lett. 2006 Nov 6;408(1):68-72. doi: 10.1016/j.neulet.2006.08.048. Epub 2006 Sep 25.
We have recently demonstrated that apolipoprotein E (APOE)-varepsilon4 allele is a risk factor for Alzheimer disease (AD) in Tehran, Iran. The current study specifically aimed to examine whether APOE polymorphism in association with serum lipids-apolipoprotein level is a risk factor for AD in a population from Tehran, Iran. APOE polymorphism and plasma lipids, apoA1, apoB and lipoprotein (a) (Lp(a)) levels were determined in 94 AD patients and 111matched controls. Our study demonstrated a significant association between APOE polymorphism and the level of plasma lipids and apolipoprotein with AD in this population. The AD subjects had significantly lower apoA1 (p<0.001) and HDL-C (p<0.01) and higher apoB (p=0.01) and LDL-C (p=0.02) levels than that of the control group. The AD subjects carrying APOE-varepsilon4 allele had lower plasma apoA1 (t=5.2, p<0.002) and HDL-C level (t=2.7, p=0.01) but had higher plasma apoB (t=-5.4, p<0.002), LDL-C (t=-4.6, p=0.005) and total cholesterol (TC) (t=-2.7, p=0.01) than that of the non APOE-varepsilon4 carriers. These results indicated that AD patients with APOE-varepsilon4 allele has a distinct plasma lipid profile and carrier of this allele with low levels of apoA1 and HDL-C may be more susceptible to AD.
我们最近证实，载脂蛋白E（APOE）-ε4等位基因是伊朗德黑兰阿尔茨海默病（AD）的一个风险因素。本研究旨在明确APOE基因多态性与血脂-载脂蛋白水平的关联是否为伊朗德黑兰人群AD的一个风险因素。测定了94例AD患者和111例匹配对照的APOE基因多态性、血浆脂质、载脂蛋白A1、载脂蛋白B和脂蛋白（a）[Lp（a）]水平。我们的研究表明，在该人群中，APOE基因多态性与血浆脂质和载脂蛋白水平与AD之间存在显著关联。与对照组相比，AD患者的载脂蛋白A1（p<0.001）和高密度脂蛋白胆固醇（HDL-C）（p<0.01）水平显著降低，而载脂蛋白B（p=0.01）和低密度脂蛋白胆固醇（LDL-C）（p=0.02）水平显著升高。携带APOE-ε4等位基因的AD患者血浆载脂蛋白A1（t=5.2，p<0.002）和HDL-C水平（t=2.7，p=0.01）较低，但血浆载脂蛋白B（t=-5.4，p<0.002）、LDL-C（t=-4.6，p=0.005）和总胆固醇（TC）（t=-2.7，p=0.01）水平高于非APOE-ε4携带者。这些结果表明，携带APOE-ε4等位基因的AD患者具有独特的血浆脂质谱，该等位基因携带者载脂蛋白A1和HDL-C水平较低可能更容易患AD。
