Amani Hamed, Dougherty William R, Blome-Eberwein Sigrid
Easton Hospital, 250 S 21st Street, Easton, PA 18042, USA.
Burns. 2006 Nov;32(7):828-32. doi: 10.1016/j.burns.2006.04.003. Epub 2006 Sep 25.
With the cost of healthcare increasing, greater emphasis is placed on finding better ways to manage burn patients by increasing the quality of care while reducing length of hospital stay (LOS), thereby reducing overall cost. To date, this is the largest study to determine if Transcyte reduces LOS for partial thickness burns of any size or etiology.
All consecutive patients with deep partial thickness burns from April 2002 to December 2002 were reviewed (n=110) with IRB approval. Ninety-two patients were treated with dermabrasion and Transcyte only. Eighteen patients were treated with a combination of STSG and dermabrasion and Transcyte where appropriate. Our data was compared to the American Burn Association Patient Registry, as reported by Saffle et al. 1995.
The data for percent TBSA and LOS are reported as mean+/-S.E.M. One-tailed t-test was used to analyze the data. Significant difference was found in patients who were treated with dermabrasion and Transcyte compared to the population reported by Saffle et al. Patients with 0-19.9% TBSA burn treated with dermabrasion and Transcyte had LOS of 6.1 days versus 9.0 days (p<0.001). Those with 20-39.9% TBSA burn had length of stay of 17.5 days versus 25.5 days. Patients treated with STSG and Transcyte who had 40-59.9% TBSA burn had length of stay of 39.7 days versus 44.6 days. Those treated with dermabrasion and Transcyte alone had length of stay of 31 days.
This is the first study comparing burns of all sizes treated with dermabrasion and Transcyte with a known population receiving standard therapy. The authors found this new method of managing patients with partial thickness burns to be more efficacious and significantly reduces length of stay compared to traditional management.
随着医疗保健成本的增加，人们更加注重寻找更好的方法来管理烧伤患者，即提高护理质量的同时缩短住院时间（LOS），从而降低总体成本。迄今为止，这是确定Transcyte是否能缩短任何大小或病因的浅度烧伤住院时间的最大规模研究。
经机构审查委员会（IRB）批准，对2002年4月至2002年12月期间所有连续性深度浅度烧伤患者（n = 110）进行了回顾。92例患者仅接受了磨皮术和使用Transcyte治疗。18例患者在适当情况下接受了自体皮移植（STSG）、磨皮术和Transcyte联合治疗。我们的数据与Saffle等人1995年报告的美国烧伤协会患者登记数据进行了比较。
TBSA百分比和住院时间的数据报告为均值±标准误。使用单尾t检验分析数据。与Saffle等人报告的人群相比，发现接受磨皮术和Transcyte治疗的患者存在显著差异。接受磨皮术和Transcyte治疗的TBSA烧伤面积为0 - 19.9%的患者住院时间为6.1天，而对照组为9.0天（p < 0.001）。TBSA烧伤面积为20 - 39.9%的患者住院时间为17.5天，而对照组为25.5天。接受STSG和Transcyte治疗且TBSA烧伤面积为40 - 59.9%的患者住院时间为39.7天，而对照组为44.6天。仅接受磨皮术和Transcyte治疗的患者住院时间为31天。
这是第一项将接受磨皮术和Transcyte治疗的所有大小烧伤与接受标准治疗的已知人群进行比较的研究。作者发现，这种管理浅度烧伤患者的新方法比传统管理方法更有效，且能显著缩短住院时间。
