Tilg Herbert, Moschen Alexander R
Christian Doppler Research Laboratory for Gut Inflammation and Department of Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria.
Nat Rev Immunol. 2006 Oct;6(10):772-83. doi: 10.1038/nri1937. Epub 2006 Sep 22.
There has been much effort recently to define the role of adipocytokines, which are soluble mediators derived mainly from adipocytes (fat cells), in the interaction between adipose tissue, inflammation and immunity. The adipocytokines adiponectin and leptin have emerged as the most abundant adipocyte products, thereby redefining adipose tissue as a key component not only of the endocrine system, but also of the immune system. Indeed, as we discuss here, several adipocytokines have a central role in the regulation of insulin resistance, as well as many aspects of inflammation and immunity. Other adipocytokines, such as visfatin, have only recently been identified. Understanding this rapidly growing family of mainly adipocyte-derived mediators might be of importance in the development of new therapies for obesity-associated diseases.
最近人们付出了很多努力来确定脂肪细胞因子的作用，脂肪细胞因子是主要来源于脂肪细胞的可溶性介质，在脂肪组织、炎症和免疫之间的相互作用中发挥作用。脂联素和瘦素这两种脂肪细胞因子已成为最丰富的脂肪细胞产物，从而将脂肪组织重新定义为不仅是内分泌系统的关键组成部分，也是免疫系统的关键组成部分。事实上，正如我们在此所讨论的，几种脂肪细胞因子在胰岛素抵抗的调节以及炎症和免疫的许多方面都起着核心作用。其他脂肪细胞因子，如内脂素，直到最近才被发现。了解这个主要由脂肪细胞衍生的介质的快速增长的家族，可能对肥胖相关疾病新疗法的开发具有重要意义。
