Daoud Mohammed S, Alshareef Fahad H, Alnaami Abdullah M, Amer Osama E, Hussain Syed D, Al-Daghri Nasser M
Department of Biochemistry, College of Science, King Saud University, P. O. 2455, Riyadh, 11451, Saudi Arabia.
Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Sci Rep. 2025 Aug 6;15(1):28794. doi: 10.1038/s41598-025-14091-z.
Obesity is a significant health concern which can lead to chronic conditions such as heart disease, type 2 diabetes, and cancer. We investigated the impact of obesity on the levels of circulating serum Lipocalin-2 and adipocytokines. A total of 80 consenting participants (50% females) aged 18-60 were enrolled and divided into standard (Group 1) and obese (Group 2) based on their height, weight, age, and body mass index. Changes in LCN-2, adipokines, and inflammatory markers in adults with obesity who took part in a 12-month lifestyle modification program were monitored. The study found that in normal-weight follow-up participants, LCN-2 was positively associated with resistin (R = 0.69, P < 0.001). In the obese group (N = 41), the circulating LCN-2 concentration was positively correlated with the resistin (R = 0.87, P < 0.001) and adiponectin (R = 0.54, P = 0.001). This study highlights the strong associations between circulating LCN-2 and key adipocytokines, particularly in individuals with obesity, underscoring the biomarker's potential role in metabolic dysregulation. The study emphasizes the need for customized interventions and individualized healthcare approaches considering the heterogenous effects of obesity.
肥胖是一个重大的健康问题，可能导致心脏病、2型糖尿病和癌症等慢性疾病。我们研究了肥胖对循环血清脂质运载蛋白-2和脂肪细胞因子水平的影响。共有80名年龄在18至60岁之间的自愿参与者（50%为女性）入组，并根据他们的身高、体重、年龄和体重指数分为标准组（第1组）和肥胖组（第2组）。对参加为期12个月生活方式改善计划的肥胖成年人的脂质运载蛋白-2、脂肪细胞因子和炎症标志物的变化进行了监测。研究发现，在体重正常的随访参与者中，脂质运载蛋白-2与抵抗素呈正相关（R = 0.69，P < 0.001）。在肥胖组（N = 41）中，循环脂质运载蛋白-2浓度与抵抗素（R = 0.87，P < 0.001）和脂联素（R = 0.54，P = 0.001）呈正相关。这项研究突出了循环脂质运载蛋白-2与关键脂肪细胞因子之间的紧密关联，尤其是在肥胖个体中，强调了该生物标志物在代谢失调中的潜在作用。该研究强调了考虑到肥胖的异质性影响，需要采取定制化干预措施和个性化医疗方法。
