Giaroli A, Sananes C, Sardi J E, Maya A G, Bastardas M L, Snaidas L, Rueda N G, Vighi S, di Paola G R
Oncology Department, Buenos Aires University, Argentina.
Gynecol Oncol. 1990 Oct;39(1):34-9. doi: 10.1016/0090-8258(90)90395-2.
One hundred and sixty-nine patients with squamous cancer of the cervix uteri treated with three courses of neoadjuvant chemotherapy with the modified VBP scheme are presented. All were subjected to a Wertheim-Meigs operation with paraaortic lymph-adenectomy. The incidence of lymph node metastases is analyzed according to clinical stage, tumor volume, residual tumor in the surgical specimen, and clinical response to neoadjuvant chemotherapy. A significant decrease in the incidence of lymph node involvement was observed in good responders. Survival rates, after 2 years of follow-up, improved in those cases with small residual tumor, negative parametria, and negative nodes.
