Department of Gynecologic Oncology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Molewaterplein 40, 3015GD, Rotterdam, The Netherlands.
Department of Urology, Erasmus MC Cancer Institute, University Medical Center, Molewaterplein 40, 3015GD, Rotterdam, The Netherlands.
Virchows Arch. 2023 Sep;483(3):431-434. doi: 10.1007/s00428-023-03559-w. Epub 2023 May 15.
Diagnosis of lymph node metastases in pelvic lymph node dissection (PLND) is important for staging and treatment. Standard practice is to submit visible or palpable lymph nodes for histology. We assessed the added value of embedding all residual fatty tissue.Patients (n = 85) who underwent PLND for cervical (n = 50) or bladder cancer (n = 35) between 2017 and 2019 were included. Study approval was obtained (MEC-2022-0156, 18.03.2022, retrospectively registered).The median lymph node yield with conventional pathological dissection was 21 nodes (Interquartile range (IQR) 18-28). This led to discovery of positive lymph nodes in 17 (20%) patients. Extended pathological assessment found 7 (IQR 3-12) additional nodes, but did not result in identification of more node metastases.Histopathological analysis of residual fatty tissue harvested at PLND resulted in an increased lymph node yield, but not in the detection of additional lymph node metastases.
在盆腔淋巴结清扫术 (PLND) 中诊断淋巴结转移对于分期和治疗很重要。标准做法是将可见或可触及的淋巴结送检进行组织学检查。我们评估了嵌入所有剩余脂肪组织的附加价值。
2017 年至 2019 年间，50 例宫颈癌和 35 例膀胱癌患者接受了 PLND 治疗，纳入了这项研究。研究获得了机构审查委员会的批准（MEC-2022-0156，2022 年 3 月 18 日，回顾性注册）。
常规病理检查的中位淋巴结检出数为 21 个（四分位距 (IQR) 18-28）。这导致 17 名（20%）患者的阳性淋巴结被发现。扩展的病理评估发现了 7 个（IQR 3-12）额外的淋巴结，但没有发现更多的淋巴结转移。
PLND 切除的剩余脂肪组织的组织病理学分析导致淋巴结检出数增加，但没有发现更多的淋巴结转移。
