Sitek Jan Cezary
Hudavdelingen, Rikshospitalet-Radiumhospitalet, 0027 Oslo.
Tidsskr Nor Laegeforen. 2006 Sep 21;126(18):2370-2.
Vitiligo is an acquired pigmentary skin disorder that affects 0.5-2% of the population. Many patients contact their physician and alternative therapists for help. This review article presents an update of knowledge about vitiligo and is aimed at physicians that treat this patient group.
The article is based on literature identified on PubMed, textbooks in Dermatology and supplemented by clinical experience.
Vitiligo is characterized by the absence of melanocytes in skin and hair follicles. The pathogenesis is complex with genetic, autoimmune and toxic contributors. Clinically well-defined milk-white maculae are seen in the skin, with a wide variety of spread and distribution. The debut of vitiligo is often in childhood and adolescence. Investigations indicate that vitiligo affects quality in life for both children and adults. Treatment of vitiligo is a challenge. Phototherapy with narrowband UVB or topical therapy with tacrolimus ointment or potent steroids may be indicated in some cases, but the effect is not well documented.
白癜风是一种获得性色素性皮肤病，影响着0.5%-2%的人群。许多患者会联系医生和替代疗法治疗师寻求帮助。这篇综述文章介绍了关于白癜风的最新知识，目标读者是治疗该患者群体的医生。
本文基于在PubMed上检索到的文献、皮肤病学教科书，并辅以临床经验撰写而成。
白癜风的特征是皮肤和毛囊中黑素细胞缺失。其发病机制复杂，涉及遗传、自身免疫和毒性因素。临床上可见皮肤出现界限清晰的乳白色斑片，有多种扩散和分布形式。白癜风通常在儿童和青少年时期发病。调查表明，白癜风会影响儿童和成人的生活质量。白癜风的治疗是一项挑战。在某些情况下，可采用窄谱中波紫外线光疗或外用他克莫司软膏或强效类固醇进行治疗，但疗效尚无充分记录。
