Department of Dermatology, Tianjin First Central Hospital, School of Medicine, Nankai University, No. 24, Fukang Road, Nankai District, Tianjin, 300192, China.
Lasers Med Sci. 2024 Mar 8;39(1):90. doi: 10.1007/s10103-024-04033-y.
This study aimed to investigate the effects and safety of 308 nm excimer laser (308 nm EL) and tacrolimus ointment (TO) in the treatment of facial vitiligo (FV). We searched Cochrane Library, PUBMED, EMBASE, CNKI, and WANGFANG from inception to June 1, 2023. Outcomes included overall response rate (ORR), total adverse reaction rate (TARR), recurrence rate at 3-month (RR-3) and recurrence rate at 6-month (RR-6). The outcome data were presented as odds ratios (OR) with 95% confidence intervals (CI). The risk of bias was assessed by Cochrane risk-of-bias tool and data analysis was performed by RevMan 5.4 software. This study included a total of 19 trials involving 2085 patients. When comparing 308 nm EL monotherapy with 308 nm EL plus TO, significant differences in the ORR (OR = 4.29, 95% CI [2.97, 6.19], I = 0%, P < 0.001), RR-3 (OR = 0.18, 95% CI [0.05, 0.69], I = 0%, P = 0.01), and RR-6 (OR = 0.38, 95% CI [0.14, 1.03], I = 39%, P = 0.06) were found between the two managements. When comparing TO monotherapy with TO plus 308 nm EL, its results showed significant differences in the ORR (OR = 4.21, 95% CI [2.90, 6.11], I = 0%, P < 0.001), TARR (OR = 0.42, 95% CI [0.22, 0.81], I = 4%, P = 0.009), and RR-3 (OR = 0.32, 95% CI [0.01, 8.03], P = 0.49) between the two modalities. The results of this study suggest that the combination of 308 nm EL and TO is more effective than either treatment alone for the treatment of FV.
本研究旨在探讨 308nm 准分子激光（308nm EL）和他克莫司软膏（TO）治疗面部白癜风（FV）的疗效和安全性。我们检索了 Cochrane 图书馆、PUBMED、EMBASE、CNKI 和 WANGFANG，检索时间从建库至 2023 年 6 月 1 日。结局指标包括总有效率（ORR）、总不良反应发生率（TARR）、3 个月时的复发率（RR-3）和 6 个月时的复发率（RR-6）。结局数据以比值比（OR）和 95%置信区间（CI）表示。使用 Cochrane 偏倚风险工具评估风险偏倚，采用 RevMan 5.4 软件进行数据分析。本研究共纳入 19 项试验，涉及 2085 例患者。与 308nm EL 单药治疗相比，308nm EL 联合 TO 治疗的 ORR（OR=4.29，95%CI[2.97,6.19]，I=0%，P<0.001）、RR-3（OR=0.18，95%CI[0.05,0.69]，I=0%，P=0.01）和 RR-6（OR=0.38，95%CI[0.14,1.03]，I=39%，P=0.06）差异均有统计学意义。与 TO 单药治疗相比，TO 联合 308nm EL 治疗的 ORR（OR=4.21，95%CI[2.90,6.11]，I=0%，P<0.001）、TARR（OR=0.42，95%CI[0.22,0.81]，I=4%，P=0.009）和 RR-3（OR=0.32，95%CI[0.01,8.03]，P=0.49）差异均有统计学意义。本研究结果提示，308nm EL 联合 TO 治疗 FV 比单独使用任何一种药物更有效。
